CYB5R3 and SBF1

		CYB5R3	SBF1
Description		cytochrome b5 reductase 3	SET binding factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Hemoglobin Complex Membrane Mitochondrial Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Body Cell Projection Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Oxidoreductase Activity Nitrite Reductase (NO-forming) Activity FAD Binding	Guanyl-nucleotide Exchange Factor Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Circulation Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process	Protein Dephosphorylation Spermatogenesis Spermatid Development
Pathways		Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation	Synthesis of PIPs at the ER membrane RAB GEFs exchange GTP for GDP on RABs
Drugs		NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia
GWAS		Initial pursuit acceleration ( 29064472)
Interacting Genes		78 interacting genes: ADAM33 AGTRAP AIG1 ALG8 APOL3 AQP6 ASGR1 ATP13A1 BET1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB561D2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LNPEP LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PEX16 PLLP PLP1 PNLIPRP1 RABAC1 REEP4 REEP6 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC30A3 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM147 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 UNC50 UNC93B1 UPK1B UPK2 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 YIPF4 ZDHHC15	7 interacting genes: AATK HSPB1 KMT2A MTMR2 PDPK1 SUV39H1 TNFSF11
Entrez ID		1727	6305
HPRD ID		08942	06788
Ensembl ID		ENSG00000100243	ENSG00000100241
Uniprot IDs		P00387	A0A8J8YTQ8 O95248
PDB IDs		1UMK 7THG 7TNV 7TSW 7W3O
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Cytoplasmic Vesicle Membrane Golgi Apparatus Protein Binding Establishment Of Protein Localization To Membrane Golgi Membrane Bile Acid:sodium Symporter Activity Cytoplasmic Vesicle Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport	Cellular Response To Growth Factor Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Multicellular Organismal Development Negative Regulation Of Protein Kinase C Signaling Response To Growth Factor Regulation Of Canonical NF-kappaB Signal Transduction Cell Development 3-phosphoinositide-dependent Protein Kinase Activity Nitric-oxide Synthase Complex Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Nitrite Reductase (NO-forming) Activity Regulation Of Protein Kinase C Signaling Positive Regulation Of Vasculature Development Regulation Of Endothelial Cell Migration Positive Regulation Of Angiogenesis Anterograde Axonal Protein Transport Protein Kinase C Inhibitor Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Developmental Process T-helper 2 Cell Differentiation Anatomical Structure Homeostasis Tissue Homeostasis Unmethylated CpG Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity MLL1/2 Complex Methyltransferase Activity Negative Regulation Of Heterochromatin Formation Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity Minor Groove Of Adenine-thymine-rich DNA Binding Methylation Hemopoiesis Multicellular Organismal-level Homeostasis Circadian Rhythm Regulation Of Heterochromatin Formation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Calcium-mediated Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Histone H3K9 Trimethyltransferase Activity Histone H3K9me2 Methyltransferase Activity Regulation Of Transcription By Glucose RDNA Heterochromatin Formation ENoSc Complex RDNA Heterochromatin Tooth Eruption Positive Regulation Of Osteoclast Development Positive Regulation Of Fever Generation
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