LIG3 and PNKP

Number of citations of the paper that reports this interaction (PMID 11163244)
104

Data Source:
BioGRID (two hybrid)

		LIG3	PNKP
Gene Name		ligase III, DNA, ATP-dependent	polynucleotide kinase 3-phosphatase
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Mitochondrion DNA Ligase III-XRCC1 Complex	Nucleus Nucleoplasm Nucleolus Membrane
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Nucleotide Kinase Activity Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Mitochondrion Organization Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Recombination Cell Division DNA Biosynthetic Process	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Dephosphorylation DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation
Pathways		Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs		Bleomycin
Diseases
GWAS		QT interval ( 19305408)
Protein-Protein Interactions		9 interactors: APP JTB NEIL1 PARP1 PNKP TDP1 XRCC1 XRCC5 XRCC6	17 interactors: APP GZMK IKZF1 KDM1A KRTAP4-12 LIG3 MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		3980	11284
HPRD ID		02966	09284
Ensembl ID		ENSG00000005156	ENSG00000039650
Uniprot IDs		E5KLB5 E5KLB6 P49916	Q96T60
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG	2BRF 2W3O
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Hyperosmotic Salinity Response Cellular Response To Stress Double-strand Break Repair Cellular Response To X-ray Base-excision Repair Response To Stress Telomere Maintenance Establishment Of Integrated Proviral Latency DNA Damage Response, Detection Of DNA Damage Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Cellular Response To Salt Stress Single Strand Break Repair Response To Oxidative Stress Nucleobase-containing Compound Metabolic Process Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Cellular Nitrogen Compound Metabolic Process Hyperosmotic Response Cellular Response To Osmotic Stress Response To X-ray Nitrogen Compound Metabolic Process Response To Salt Stress Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Response To Ionizing Radiation Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Type I Interferon Production Response To Abiotic Stimulus Response To Osmotic Stress Negative Regulation Of Cellular Metabolic Process Nucleotide-excision Repair Regulation Of Type I Interferon Production Synaptic Growth At Neuromuscular Junction Negative Regulation Of Nuclease Activity Polynucleotide 3' Dephosphorylation Homeostatic Process Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation DNA Catabolic Process Cellular Response To Radiation Response To Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Base-excision Repair Nucleobase-containing Compound Metabolic Process DNA Ligation Involved In DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Ligation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Repair Chromatin Modification Regulation Of RNA Metabolic Process Response To Stress Gene Expression Hemopoiesis Neuron Apoptotic Process Cellular Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Regulation Of Primitive Erythrocyte Differentiation Neuron Death Immune System Development Biosynthetic Process Chromatin Organization Regulation Of Gene Expression Leukocyte Cell-cell Adhesion Regulation Of Metabolic Process Negative Regulation Of Viral Process Leukocyte Differentiation
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	14q32 amplifies ataxia atm atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		ageing ascribes attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	14q32 amplifies ataxia atnx3 atxn3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?		atm