LIG3 and JTB

Number of citations: 36 (PubMedID 12897160)
Data Source: HPRD (in vivo)

		LIG3	JTB
Name		DNA ligase 3	jumping translocation breakpoint
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix DNA Ligase III-XRCC1 Complex	Cytoplasm Mitochondrion Centrosome Spindle Cytoskeleton Plasma Membrane Membrane Midbody
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding	Protein Kinase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Mitochondrion Organization V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Metabolic Process Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining	Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Apoptotic Mitochondrial Changes Regulation Of Cell Population Proliferation Positive Regulation Of Protein Kinase Activity Cell Division
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	None
Drugs		Bleomycin	None
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165 ) Electrocardiographic traits (multivariate) ( 32602732 ) Night sleep phenotypes ( 27126917 ) Nonobstructive coronary artery disease ( 26534935 ) Pulse pressure ( 30224653 ) QT interval ( 19305408 24952745 29874175 30679814 ) TPE interval (resting) ( 32386560 )	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cooked vegetable consumption ( 32066663 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		8 interacting genes: APP JTB MALAT1 PARP1 TDP1 XRCC1 XRCC5 XRCC6	4 interacting genes: APP ELOC LIG3 ZXDC
Entrez ID		3980	10899
HPRD ID		02966	05240
Ensembl ID		ENSG00000005156	ENSG00000143543
Uniprot IDs		B7Z6I3 P49916	O76095
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1	2KJX
GO Terms Enriched among Interactors		Double-strand Break Repair Damaged DNA Binding Telomere Maintenance Telomere Organization DNA End Binding Ku70:Ku80 Complex Protein-DNA Complex Site Of DNA Damage Chromosome, Telomeric Region Regulation Of Base-excision Repair DNA Repair Response To Gamma Radiation Regulation Of Phosphorus Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase Complex DNA Recombination DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex DNA Metabolic Process Positive Regulation Of Phosphate Metabolic Process Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding DNA Damage Response Chromosome Organization Single Strand Break Repair Regulation Of Telomere Maintenance Positive Regulation Of Protein Kinase Activity Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Innate Immune Response Recombinational Repair Response To Ionizing Radiation Cellular Response To Radiation Telomeric DNA Binding Regulation Of Catalytic Activity Cellular Response To Gamma Radiation ATP-dependent Activity, Acting On DNA Innate Immune Response Negative Regulation Of Telomere Maintenance DNA Helicase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Chromosome Regulation Of Chromosome Organization Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Phosphorylation Regulation Of Kinase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Mitochondrial DNA Replication Negative Regulation Of Mitochondrial DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Ligase III-XRCC1 Complex DNA Ligase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Mitochondrial DNA Metabolic Process Target-directed MiRNA Degradation Elongin Complex Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway LRR Domain Binding Axon Choice Point Recognition Mitochondrial DNA Repair Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Double-strand Break Repair Via Alternative Nonhomologous End Joining Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Blood Circulation