LIG3

Gene Name		ligase III, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	DNA Ligation Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Mitochondrion Organization Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Recombination Cell Division DNA Biosynthetic Process
Pathways		Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs		Bleomycin
Diseases
GWAS		QT interval ( 19305408)
Protein-protein Interactions		9 interactors: APP JTB NEIL1 PARP1 PNKP TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		3980
HPRD ID		02966
Ensembl ID		ENSG00000005156
Uniprot IDs		E5KLB5 E5KLB6 P49916
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?		DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Hyperosmotic Salinity Response Cellular Response To Stress Double-strand Break Repair Cellular Response To X-ray Base-excision Repair Response To Stress Telomere Maintenance Establishment Of Integrated Proviral Latency DNA Damage Response, Detection Of DNA Damage Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Cellular Response To Salt Stress Single Strand Break Repair Response To Oxidative Stress Nucleobase-containing Compound Metabolic Process Response To Radiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Cellular Nitrogen Compound Metabolic Process Hyperosmotic Response Cellular Response To Osmotic Stress Response To X-ray Nitrogen Compound Metabolic Process Response To Salt Stress Nucleic Acid Phosphodiester Bond Hydrolysis Cellular Response To Ionizing Radiation Cellular Response To Stimulus DNA Duplex Unwinding DNA Geometric Change Positive Regulation Of Type I Interferon Production Response To Abiotic Stimulus Response To Osmotic Stress Negative Regulation Of Cellular Metabolic Process Nucleotide-excision Repair Regulation Of Type I Interferon Production Synaptic Growth At Neuromuscular Junction Negative Regulation Of Nuclease Activity Polynucleotide 3' Dephosphorylation Homeostatic Process Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Protein Poly-ADP-ribosylation DNA Catabolic Process Cellular Response To Radiation Response To Stimulus
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig4 mechanistically nhej overhang parp1 rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining