LIG3

Name	DNA ligase 3
Structure
Interactors	8 interactors: APP JTB MALAT1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix DNA Ligase III-XRCC1 Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Mitochondrion Organization V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Metabolic Process Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs	Bleomycin
GWAS	Acute post-radiotherapy pain in breast cancer ( 31196165 ) Electrocardiographic traits (multivariate) ( 32602732 ) Night sleep phenotypes ( 27126917 ) Nonobstructive coronary artery disease ( 26534935 ) Pulse pressure ( 30224653 ) QT interval ( 19305408 24952745 29874175 30679814 ) TPE interval (resting) ( 32386560 )
Entrez ID	3980
HPRD ID	02966
Ensembl ID	ENSG00000005156
Uniprot IDs	B7Z6I3 P49916
PDB IDs	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1
GO Terms Enriched among Interactors ?	Double-strand Break Repair Damaged DNA Binding Telomere Maintenance Telomere Organization DNA End Binding Ku70:Ku80 Complex Protein-DNA Complex Site Of DNA Damage Chromosome, Telomeric Region Regulation Of Base-excision Repair DNA Repair Response To Gamma Radiation Regulation Of Phosphorus Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase Complex DNA Recombination DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex DNA Metabolic Process Positive Regulation Of Phosphate Metabolic Process Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding DNA Damage Response Chromosome Organization Single Strand Break Repair Regulation Of Telomere Maintenance Positive Regulation Of Protein Kinase Activity Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Innate Immune Response Recombinational Repair Response To Ionizing Radiation Cellular Response To Radiation Telomeric DNA Binding Regulation Of Catalytic Activity Cellular Response To Gamma Radiation ATP-dependent Activity, Acting On DNA Innate Immune Response Negative Regulation Of Telomere Maintenance DNA Helicase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Chromosome Regulation Of Chromosome Organization Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Phosphorylation Regulation Of Kinase Activity