IL31RA and LIFR

Number of citations of the paper that reports this interaction (PubMedID 14504285)
0

Data Source:
HPRD (in vivo)

		IL31RA	LIFR
Description		interleukin 31 receptor A	LIF receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Axon Presynaptic Membrane Cell Projection Receptor Complex Synapse	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Cytokine Receptor Activity Protein Kinase Binding Cytokine Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	MAPK Cascade Glandular Epithelial Cell Differentiation Immune System Process Acute Inflammatory Response To Antigenic Stimulus Defense Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Homeostatic Process Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Cell Surface Receptor Signaling Pathway Via STAT Defense Response To Other Organism	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling
Drugs
Diseases			Stuve-Wiedemann syndrome
GWAS		Crohn's disease ( 23128233)	Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)
Interacting Genes		2 interacting genes: IL6ST LIFR	12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		133396	3977
HPRD ID		17145	01048
Ensembl ID		ENSG00000164509	ENSG00000113594
Uniprot IDs		B4DNJ2 Q8NI17	A8K1Z4 P42702
PDB IDs			3E0G 8D6A 8D74 8D7R 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Cytokine Binding Growth Factor Binding Cytokine Receptor Activity Receptor Complex Interleukin-27 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex External Side Of Plasma Membrane Interleukin-11 Receptor Activity Interleukin-11 Binding Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding Interleukin-27-mediated Signaling Pathway Response To Peptide Response To Cytokine Intestinal Epithelial Cell Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Platelet Aggregation Positive Regulation Of Astrocyte Differentiation T-helper 17 Cell Lineage Commitment Columnar/cuboidal Epithelial Cell Development Protein Tyrosine Kinase Activator Activity Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cell Population Proliferation Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Platelet Aggregation T Cell Lineage Commitment Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Regulation Of Acute Inflammatory Response	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Phosphorylation Leukemia Inhibitory Factor Receptor Binding Cell Development Regulation Of Phosphorus Metabolic Process Ciliary Neurotrophic Factor Receptor Complex Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Protein Modification Process Interleukin-11 Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Binding Enzyme-linked Receptor Protein Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Cytokine Receptor Activity Regulation Of Inflammatory Response Response To Epidermal Growth Factor Ciliary Neurotrophic Factor Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Interleukin-6 Receptor Binding Interleukin-11-mediated Signaling Pathway Regulation Of Defense Response Negative Regulation Of Neutrophil Activation Epidermal Growth Factor Receptor Signaling Pathway Cytokine Activity Muscle Organ Morphogenesis Negative Regulation Of Hormone Secretion Regulation Of Multicellular Organismal Process ERBB Signaling Pathway
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