TRIM22 and LGALS3

Number of citations of the paper that reports this interaction (PubMedID 27693506)
53

Data Source:
BioGRID (pull down)

		TRIM22	LGALS3
Description		tripartite motif containing 22	galectin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cajal Body Nuclear Body Nuclear Speck	Immunological Synapse Extracellular Region Extracellular Space Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Signaling Receptor Inhibitor Activity Chemoattractant Activity Laminin Binding Disaccharide Binding Oligosaccharide Binding Molecular Condensate Scaffold Activity Receptor Ligand Inhibitor Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Regulation Of DNA-templated Transcription Immune Response Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process Antiviral Innate Immune Response	Immune System Process Monocyte Chemotaxis MRNA Processing RNA Splicing Cell Differentiation Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Killing Of Cells Of Another Organism Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis NK T Cell Activation Negative Regulation Of NK T Cell Activation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling	Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells
Drugs			2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose
Diseases
GWAS		Coronary artery disease ( 29212778) Malaria ( 31844061)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Leukoderma in response to rhododendrol ( 32558222) Protein biomarker ( 23056639) Testicular germ cell tumor ( 28604728)
Interacting Genes		13 interacting genes: CASK CIC CREB1 LGALS3 LGALS8 MFHAS1 PLEKHF2 RAF1 RERE TAF7 UBE2D1 USP7 ZZZ3	32 interacting genes: ANXA1 APP C1GALT1C1 CRX CSNK1A1 CSNK2A1 CSNK2A2 CUBN ELN FCGR2A GEMIN4 GOLGA2 INCA1 KIF16B LGALS3BP LIM2 LINC00632 MCAM MCPH1 MEFV MMP2 MYOC PPIG PRR13 SNCA SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6 ZFTRAF1
Entrez ID		10346	3958
HPRD ID		05951	01090
Ensembl ID		ENSG00000132274	ENSG00000131981
Uniprot IDs		B4DQS5 Q8IYM9	A0A024R693 P17931
PDB IDs			1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6RZF 6RZG 6RZH 6RZI 6RZJ 6RZK 6RZL 6RZM 6TF6 6TF7 6Y4C 6Y78 6ZVF 7BE3 7CXA 7DF5 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX 8BZ3 8ITX 8ITZ 8OJI 8OJK 8OJM 8OJO 8PBF 8PF9 8PFF 8PPN 8RMT 8RMU 8RMV 8RR7 8RR8 8RR9 8RRA 8RRB 8RRC 8RRE 8RRF 8RRG 8S67 8YMD 8Z1S 8Z1T 8Z25 8ZUV
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Histone Acetyltransferase Binding Positive Regulation Of Calcium Ion Import Cerebellar Purkinje Cell Layer Maturation Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Radial Glia Guided Migration Of Purkinje Cell Response To Dehydroepiandrosterone Positive Regulation Of Cardiac Muscle Tissue Development ATF4-CREB1 Transcription Factor Complex Hormone Transport Regulation Of DNA-templated Transcription Initiation Intracellular Signal Transduction Positive Regulation Of Transforming Growth Factor Beta3 Production Hormone Secretion Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Response To Hypobaric Hypoxia MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II MRNA Transcription Chemotaxis To Arachidonate Transcription By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of NK T Cell Activation Negative Regulation Of Signal Transduction Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Calcium Ion Transport Lymphatic Endothelial Cell Migration Death-inducing Signaling Complex Assembly Negative Regulation Of MHC Class I Biosynthetic Process TFIIH-class Transcription Factor Complex Binding Spermine Transport P-TEFb Complex Binding Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling	Regulation Of Autophagy Positive Regulation Of Autophagy Protein Kinase CK2 Complex Positive Regulation Of Catabolic Process Negative Regulation Of Catabolic Process Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Defense Response Response To External Biotic Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Vesicle Fusion Response To Interleukin-1 Regulation Of Proteolysis Protein Tetramerization Regulation Of Protein Catabolic Process Regulation Of Neurotransmitter Uptake Ubiquitin Protein Ligase Activity Negative Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Defense Response Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Inflammatory Response Response To Other Organism Vesicle-mediated Transport Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Identical Protein Binding Negative Regulation Of Autophagy Regulation Of Receptor Recycling
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