TRIM22 and ZZZ3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TRIM22	ZZZ3
Gene Name		tripartite motif containing 22	zinc finger, ZZ-type containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Speck	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Nuclear Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Zinc Ion Binding Ligase Activity	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Immune Response Response To Virus Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein Trimerization Negative Regulation Of Nucleic Acid-templated Transcription	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		7 interactors: CASK CIC CREB1 RERE TAF7 USP7 ZZZ3	16 interactors: BLZF1 DNAJB11 EPS8 FAM124A GATA1 HOXA1 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513
Entrez ID		10346	26009
HPRD ID		05951	15907
Ensembl ID		ENSG00000132274	ENSG00000036549
Uniprot IDs		B4DQS5 Q8IYM9	Q8IYH5
PDB IDs			2FC7 2YUM
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Lung Alveolus Development Lactation Transcription, DNA-templated RNA Biosynthetic Process Protein Stabilization Spermine Transport Regulation Of Metabolic Process Body Fluid Secretion Regulation Of Protein Stability RNA Metabolic Process Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Development Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Maintenance Of DNA Methylation Lung Development Respiratory Tube Development Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription By Competitive Promoter Binding Cellular Metabolic Process Respiratory System Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Keratinocyte Proliferation Lung Saccule Development Positive Regulation Of Calcium Ion Import Multicellular Organismal Development Cellular Response To Zinc Ion Type I Pneumocyte Differentiation Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Estrogen Receptor Signaling Pathway Histone Deubiquitination	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Optokinetic Behavior Abducens Nerve Formation Facial Nucleus Development Basophil Differentiation Eosinophil Fate Commitment Eosinophil Differentiation Rhombomere 4 Development Actin Polymerization-dependent Cell Motility Semicircular Canal Formation Transcriptional Activation By Promoter-enhancer Looping Rhombomere 3 Development Rhombomere 5 Development Positive Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Definitive Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Exit From Mitosis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Neurocranium Morphogenesis Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Behavioral Response To Ethanol Outer Ear Morphogenesis
Tagcloud ?		addresses bisulfite blotting breast clonogenic correlates de genotoxic greatly h1299 hypermethylation inducible instead leukemic lines malignant mammary monoclonal motif negatively notion null p53 panel relapse similarly supported tripartite wilms	5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist
Tagcloud (Difference) ?		addresses bisulfite blotting breast clonogenic correlates de genotoxic greatly h1299 hypermethylation inducible instead leukemic lines malignant mammary monoclonal motif negatively notion null p53 panel relapse similarly supported tripartite wilms	5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hnf4g hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist
Tagcloud (Intersection) ?