LFNG and NOTCH2

Number of citations of the paper that reports this interaction (PMID 11346656)
20

Data Source:
HPRD (in vitro, in vivo)

		LFNG	NOTCH2
Gene Name		LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	notch 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Golgi Membrane Vesicle	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Membrane Receptor Complex
	Molecular Function	Molecular_function O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding	Receptor Activity Calcium Ion Binding Protein Binding Ligand-activated RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
	Biological Process	Ovarian Follicle Development Somitogenesis Female Meiotic Division Notch Signaling Pathway Compartment Pattern Specification Metabolic Process Regulation Of Notch Signaling Pathway Organ Morphogenesis Regulation Of Somitogenesis Positive Regulation Of Protein Binding Positive Regulation Of Notch Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Cell Fate Determination Morphogenesis Of An Epithelial Sheet Inflammatory Response To Antigenic Stimulus Pulmonary Valve Morphogenesis Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process Humoral Immune Response Cell Cycle Arrest Notch Signaling Pathway Notch Receptor Processing Multicellular Organismal Development Determination Of Left/right Symmetry Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Organ Morphogenesis Gene Expression Cell Growth Stem Cell Maintenance Hemopoiesis Embryonic Limb Morphogenesis Positive Regulation Of BMP Signaling Pathway Intracellular Receptor Signaling Pathway Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Ras Protein Signal Transduction Bone Remodeling Atrial Septum Morphogenesis Placenta Blood Vessel Development Ciliary Body Morphogenesis Notch Signaling Involved In Heart Development Interleukin-4 Secretion
Pathways		Pre-NOTCH Processing in Golgi Signaling by NOTCH Pre-NOTCH Expression and Processing	Notch-HLH transcription pathway Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS			Type 2 diabetes ( 18372903)
Protein-Protein Interactions		3 interactors: APP NOTCH1 NOTCH2	18 interactors: CNTN1 CRKL DLL1 DTX1 EGFL7 GSK3B JAG1 JAG2 LFNG MAML1 MAML2 MAML3 MFNG MYOC PSEN1 PSEN2 RBPJ SMAD1
Entrez ID		3955	4853
HPRD ID		03987	02606
Ensembl ID		ENSG00000106003	ENSG00000134250
Uniprot IDs		Q8NES3	Q04721 Q6IQ50 Q9UFD5
PDB IDs			2OO4
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Interleukin-4 Secretion Notch Signaling Involved In Heart Development Pulmonary Valve Morphogenesis Interleukin-4 Production Notch Receptor Processing Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway Growth Secretion By Cell Cardiac Septum Morphogenesis Morphogenesis Of An Epithelial Sheet Secretion Negative Regulation Of Cell Differentiation Cardiac Septum Development Regulation Of BMP Signaling Pathway Determination Of Left/right Symmetry Apoptotic Process Determination Of Bilateral Symmetry Protein Secretion Programmed Cell Death Cell Death Death Cytokine Production Cardiac Chamber Development Developmental Growth Involved In Morphogenesis Cell Growth Stem Cell Maintenance Venous Endothelial Cell Differentiation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Embryonic Limb Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Immune Response Limb Morphogenesis Reproductive Process Defense Response Negative Regulation Of Neuron Differentiation Intracellular Receptor Signaling Pathway Limb Development Vasculogenesis Involved In Coronary Vascular Morphogenesis Synaptic Growth At Neuromuscular Junction Cardiac Right Atrium Morphogenesis Mitral Valve Formation Heart Morphogenesis DNA-templated Transcription, Initiation Humoral Immune Response	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Notch Receptor Processing Regulation Of Notch Signaling Pathway Multicellular Organismal Development Pattern Specification Process Cell Fate Commitment Generation Of Neurons System Development Signal Transduction Positive Regulation Of Notch Signaling Pathway Neurogenesis Positive Regulation Of Signal Transduction Developmental Process Organ Development Signaling Anatomical Structure Morphogenesis Cell Communication Organ Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Development Regulation Of Cell Differentiation Cell Differentiation Heart Development Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Neuron Differentiation Regulation Of Cell Development Cardiovascular System Development Tissue Development Nervous System Development Cellular Response To Stimulus Cell Development Regulation Of Signaling Negative Regulation Of Neuron Differentiation Somitogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Immune System Development Regulation Of Neurogenesis Epithelium Development Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Somite Development Neuron Differentiation Anterior/posterior Pattern Specification Regulation Of Binding Segmentation Auditory Receptor Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Neurogenesis
Tagcloud ?		aldh1a2 bmpr1a cdx cdx1 chiari cmi corrections fgf8 flt1 fossa hindbrain kdr mesoderm morphometric morphometry msgn1 nkd2 nog overcame overcrowding paraxial pcf rarg rbpj1 rdh10 sclerotome somites somitogenesis underdeveloped	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Difference) ?		aldh1a2 bmpr1a cdx cdx1 chiari cmi corrections fgf8 flt1 fossa hindbrain kdr mesoderm morphometric morphometry msgn1 nkd2 nog overcame overcrowding paraxial pcf rarg rbpj1 rdh10 sclerotome somites somitogenesis underdeveloped	activates associates atypical cbf1 coactivator cofactor correlate defines deltex drosophila e47 effort gal4 hairless homolog hybrid immunoglobulin interacting jkappa jun physically ras rbp reversed rpb sapk unaffected
Tagcloud (Intersection) ?