LFNG

Description		LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Extracellular Vesicle
	Molecular Function	Transferase Activity Glycosyltransferase Activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding
	Biological Process	Ovarian Follicle Development Somitogenesis Marginal Zone B Cell Differentiation Compartment Pattern Specification Pattern Specification Process Regulation Of Notch Signaling Pathway Animal Organ Morphogenesis Regulation Of Somitogenesis T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Meiotic Cell Cycle Negative Regulation Of Notch Signaling Pathway Involved In Somitogenesis
Pathways		Pre-NOTCH Processing in Golgi Defective LFNG causes SCDO3 Somitogenesis Nephron development
Drugs
Diseases		Spondylocostal dysostosis (SCD)
GWAS		Diastolic blood pressure ( 27618452 28739976) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Systolic blood pressure ( 27618452)
Interacting Genes		3 interacting genes: APP NOTCH1 NOTCH2
Entrez ID		3955
HPRD ID		03987
Ensembl ID		ENSG00000106003
Uniprot IDs		Q8NES3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Tumor Cell Notch Signaling Pathway Atrioventricular Node Development Receptor Complex Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Regulation Of ERK1 And ERK2 Cascade Humoral Immune Response Positive Regulation Of Ras Protein Signal Transduction Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Renal Tubule Development Developmental Growth Enzyme Binding Inflammatory Response To Antigenic Stimulus Positive Regulation Of BMP Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Smooth Muscle Cell Differentiation Neuron Projection Development Regulation Of Ras Protein Signal Transduction Positive Regulation Of Apoptotic Process Heart Valve Morphogenesis Positive Regulation Of Programmed Cell Death Cardiac Muscle Tissue Development Heart Looping Cell Surface Regulation Of MiRNA Transcription Regulation Of MAPK Cascade Cardiac Septum Morphogenesis Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Small GTPase Mediated Signal Transduction Embryonic Heart Tube Morphogenesis Kidney Epithelium Development Axis Specification Embryonic Limb Morphogenesis Regulation Of MiRNA Metabolic Process Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Plasma Membrane Bounded Cell Projection Organization Cell Development Positive Regulation Of Cell Differentiation Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Epithelial Tube Morphogenesis Regulation Of BMP Signaling Pathway Liver Development Apoptotic Process Amyloid-beta Complex
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