LDHB and SUMO4

Number of citations of the paper that reports this interaction (PubMedID 16236267)
0

Data Source:
HPRD (in vivo)

		LDHB	SUMO4
Description		lactate dehydrogenase B	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Membrane Raft Extracellular Exosome Oxidoreductase Complex	Nucleus SUMO Ligase Complex
	Molecular Function	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Kinase Binding Identical Protein Binding NAD Binding	Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Lactate Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Protein Localization To Nucleus
Pathways		Pyruvate metabolism
Drugs		NADH 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid Oxamic Acid Stiripentol Artenimol
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Dupuytren's disease ( 28886342)
Interacting Genes		12 interacting genes: CEBPA CKS1B CKS2 MYCBP2 OGT PEX5 POT1 PTPRF SDCBP SUMO4 TERF1 USP40	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB1 PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		3945	387082
HPRD ID		01026	10584
Ensembl ID		ENSG00000111716	ENSG00000177688
Uniprot IDs		A0A5F9ZHM4 P07195 Q5U077	Q6EEV6
PDB IDs		1I0Z 1T2F 7DBJ 7DBK 8QDE
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomeric Loop Disassembly Telomere Capping G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Organization Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification Process Regulation Of Cellular Component Organization Chondroitin Sulfate Proteoglycan Binding Interleukin-5 Receptor Complex Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding SCF Ubiquitin Ligase Complex Circadian Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Vitamin B2 C/EBP Complex Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-5 Receptor Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly	Extracellular Exosome Protein Folding ATP-dependent Protein Folding Chaperone Unfolded Protein Binding Protein Folding Chaperone Cytoplasm Purine Nucleotide Metabolic Process Cytosol Nucleotide Metabolic Process Ubiquitin Protein Ligase Binding Ribose Phosphate Metabolic Process Regulation Of Apoptotic Process Ficolin-1-rich Granule Lumen Purine-containing Compound Metabolic Process Regulation Of Programmed Cell Death Identical Protein Binding RNA Binding Nucleoside Phosphate Metabolic Process Nicotinamide Nucleotide Metabolic Process Protein Refolding ATP Metabolic Process Secretory Granule Lumen Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Peroxiredoxin Activity Ribonucleotide Metabolic Process Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Telomerase RNA Localization To Cajal Body Mitochondrion Positive Regulation Of Telomere Maintenance Via Telomerase Oxidoreductase Activity Antioxidant Activity Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoprotein Complex Small Molecule Metabolic Process Generation Of Precursor Metabolites And Energy Response To Peptide Enzyme Binding Regulation Of Telomerase RNA Localization To Cajal Body Peroxidase Activity Nucleus Hydrogen Peroxide Metabolic Process Response To Stress Organophosphate Metabolic Process
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