LDHB and CKS2

Number of citations of the paper that reports this interaction (PubMedID 19786724)
39

Data Source:
BioGRID (pull down)

		LDHB	CKS2
Description		lactate dehydrogenase B	CDC28 protein kinase regulatory subunit 2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane Membrane Raft Extracellular Exosome Oxidoreductase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex SCF Ubiquitin Ligase Complex
	Molecular Function	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Kinase Binding Identical Protein Binding NAD Binding	Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Lactate Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Pyruvate Catabolic Process	Regulation Of Transcription By RNA Polymerase II Meiosis I Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Cell Division
Pathways		Pyruvate metabolism
Drugs		NADH 4-Hydroxy-1,2,5-oxadiazole-3-carboxylic acid Oxamic Acid Stiripentol Artenimol
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		12 interacting genes: CEBPA CKS1B CKS2 MYCBP2 OGT PEX5 POT1 PTPRF SDCBP SUMO4 TERF1 USP40	15 interacting genes: BLZF1 CCNA1 CCNB2 CDC37 CDK1 CDK3 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN
Entrez ID		3945	1164
HPRD ID		01026	00300
Ensembl ID		ENSG00000111716	ENSG00000123975
Uniprot IDs		A0A5F9ZHM4 P07195 Q5U077	P33552
PDB IDs		1I0Z 1T2F 7DBJ 7DBK 8QDE	1CKS 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Telomeric Loop Disassembly Telomere Capping G-rich Strand Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Organization Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification Process Regulation Of Cellular Component Organization Chondroitin Sulfate Proteoglycan Binding Interleukin-5 Receptor Complex Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding SCF Ubiquitin Ligase Complex Circadian Regulation Of Gene Expression Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Vitamin B2 C/EBP Complex Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Interleukin-5 Receptor Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly	Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK1 Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Kinase Binding Extracellular Exosome Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Protein Folding Chaperone Complex Endodermal Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Protein Kinase Binding Pronuclear Fusion Positive Regulation Of Organelle Organization DNA-templated DNA Replication Positive Regulation Of DNA Replication Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Symbiont-containing Vacuole Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Positive Regulation Of DNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cyclin A2-CDK1 Complex Grb2-EGFR Complex Neurofibrillary Tangle Assembly UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Smooth Muscle Cell-matrix Adhesion Meiosis I Cell Cycle Process Cyclin A1-CDK2 Complex Negative Regulation Of Caveolin-mediated Endocytosis G2/MI Transition Of Meiotic Cell Cycle HSP90-CDC37 Chaperone Complex Response To Osmotic Stress Protein Polymerization Centrosome Positive Regulation Of Cellular Component Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication
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