RECK and SIGMAR1

		RECK	SIGMAR1
Description		reversion inducing cysteine rich protein with kazal motifs	sigma non-opioid intracellular receptor 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Potential therapeutics for SARS
Drugs			Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)
Interacting Genes		43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	5 interacting genes: ANK2 GHSR ITPR3 PDZD11 SRI
Entrez ID		8434	10280
HPRD ID		05567	03580
Ensembl ID		ENSG00000122707	ENSG00000147955
Uniprot IDs		A8K9D8 O95980 Q6P9E2	A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720
PDB IDs		8TZP	5HK1 5HK2 6DJZ 6DK0 6DK1
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament
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