RECK and CTH

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RECK	CTH
Gene Name		reversion-inducing-cysteine-rich protein with kazal motifs	cystathionine gamma-lyase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Anchored Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity	Cystathionine Gamma-lyase Activity Protein Binding Calmodulin Binding Carbon-sulfur Lyase Activity Pyridoxal Phosphate Binding L-cystine L-cysteine-lyase (deaminating) Homocysteine Desulfhydrase Activity L-cysteine Desulfhydrase Activity
	Biological Process	Blood Vessel Maturation Embryo Implantation Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Cysteine Biosynthetic Process Transsulfuration Endoplasmic Reticulum Unfolded Protein Response Cellular Nitrogen Compound Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Protein Sulfhydration Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homotetramerization Hydrogen Sulfide Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Degradation of cysteine and homocysteine Sulfur amino acid metabolism Cysteine formation from homocysteine Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Cysteine 2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic Acid Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-Oxadiazol L-2-amino-3-butynoic acid
Diseases
GWAS		IgG glycosylation ( 23382691)
Protein-Protein Interactions		12 interactors: CTH KEAP1 KRT40 MEOX2 MMP9 NOTCH2NL REL TCF4 TEKT4 TRIM39 TRIM69 USHBP1	4 interactors: GUCD1 RECK SDCBP2 WDYHV1
Entrez ID		8434	1491
HPRD ID		05567	09633
Ensembl ID		ENSG00000122707	ENSG00000116761
Uniprot IDs		A8K9D8 O95980	P32929
PDB IDs			2NMP 3COG 3ELP
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Binding Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Protein-pyridoxal-5-phosphate Linkage Transsulfuration Catenin Import Into Nucleus Embryo Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Binding Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Receptor Binding Maintenance Of DNA Repeat Elements Cysteine Biosynthetic Process Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Protein Binding Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Positive Regulation Of Keratinocyte Migration Hydrogen Sulfide Metabolic Process Regulation Of Apoptotic Process Somite Specification Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Embryonic Genitalia Morphogenesis Myoblast Fate Commitment Cysteine Metabolic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Homocysteine Metabolic Process Secretory Granule Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Hindgut Morphogenesis Transcription From RNA Polymerase II Promoter Negative Regulation Of Apoptotic Signaling Pathway Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Binding Hindgut Development Ossification
Tagcloud ?		appendicular bioengineering biomechanical bones cartilaginous chondrocyte cleaving collagenase condensation crest ecm ectoderm embryological endochondral intracellularly intramembranous look mesoderm metalloproteinases mmps multipotent originate ossification osteocyte pericellular perimeter refined remodeling timps	additionally allows cbs contribution cystathionase cystathionine cysteine determination employed evaluating gamma glutathione gsh gssg h2s homogenates homoserine hplc inhibiting ketobutyrate measure propargylglycine reactions redox reflect rp synthase totally undertaken
Tagcloud (Difference) ?		appendicular bioengineering biomechanical bones cartilaginous chondrocyte cleaving collagenase condensation crest ecm ectoderm embryological endochondral intracellularly intramembranous look mesoderm metalloproteinases mmps multipotent originate ossification osteocyte pericellular perimeter refined remodeling timps	additionally allows cbs contribution cystathionase cystathionine cysteine determination employed evaluating gamma glutathione gsh gssg h2s homogenates homoserine hplc inhibiting ketobutyrate measure propargylglycine reactions redox reflect rp synthase totally undertaken
Tagcloud (Intersection) ?