RECK and MLPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RECK	MLPH
Description		reversion inducing cysteine rich protein with kazal motifs	melanophilin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome	Cytoplasm Cytosol Dendrite Cortical Actin Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity	Actin Binding Protein Binding Zinc Ion Binding Myosin Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Intracellular Protein Transport Melanosome Transport
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	Central corneal thickness ( 32528159) Heel bone mineral density ( 28869591 30598549) Height ( 33713608) Intraocular pressure ( 29617998) Prostate cancer ( 21743057)
Interacting Genes		43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	7 interacting genes: BLOC1S6 C1orf216 MTDH MYO5A RAB27A RAB27B RECK
Entrez ID		8434	79083
HPRD ID		05567	09409
Ensembl ID		ENSG00000122707	ENSG00000115648
Uniprot IDs		A8K9D8 O95980 Q6P9E2	Q9BV36
PDB IDs		8TZP
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	Pigment Granule Localization Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Melanosome Establishment Of Vesicle Localization Vesicle Localization Myosin V Binding Late Endosome Melanocyte Differentiation Pigment Cell Differentiation Exocytic Vesicle Cytoskeleton-dependent Intracellular Transport Multivesicular Body Membrane Synaptic Vesicle Transport Establishment Of Organelle Localization Anterograde Axonal Transport Pigmentation Multivesicular Body Sorting Pathway Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Apical Plasma Membrane Secretion By Cell GDP Binding Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Protein Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Organelle Localization Blood Coagulation Secretory Granule Ruffle Coagulation Secretion Hemostasis Establishment Of Protein Localization Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Complement-dependent Cytotoxicity Regulation Of Establishment Of Blood-brain Barrier Intracellular Nitric Oxide Homeostasis Exosomal Secretion Establishment Of Localization In Cell
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