RECK and SPSB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RECK	SPSB2
Description		reversion inducing cysteine rich protein with kazal motifs	splA/ryanodine receptor domain and SOCS box containing 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane Wnt Signalosome	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Coreceptor Activity Wnt-protein Binding Peptidase Inhibitor Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Blood Vessel Maturation Sprouting Angiogenesis Embryo Implantation Negative Regulation Of Extracellular Matrix Disassembly Wnt Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Cell Migration Embryonic Forelimb Morphogenesis Regulation Of Angiogenesis Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Extracellular Matrix Organization	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) IgG glycosylation ( 23382691)	Colorectal cancer ( 26965516) Refractive error ( 32231278)
Interacting Genes		43 interacting genes: ADAM12 BMF C22orf39 CCN3 CEP44 CFP CTH CTIF CYSRT1 DISC1 DYRK1A EFHC2 GLRX3 INCA1 KEAP1 KLHL20 KRT40 KRTAP10-8 KRTAP13-2 KRTAP26-1 KRTAP3-1 LCN1 MEOX2 MLPH MMP9 MTNR1B NBPF19 NDUFB7 NOTCH2NLA NR4A3 NUDT16L1 OXER1 PRIM2 REL SPSB2 SSC4D TCF4 TEKT4 TRIM39 TRIM69 USHBP1 ZNF438 ZNF704	11 interacting genes: APP DDX4 FNDC3B GALNT15 NOS2 NRF1 PRMT1 RECK SMARCD1 TRIM55 TRIM63
Entrez ID		8434	84727
HPRD ID		05567	13610
Ensembl ID		ENSG00000122707	ENSG00000111671
Uniprot IDs		A8K9D8 O95980 Q6P9E2	Q99619
PDB IDs		8TZP	3EMW 5XN3 6DN5 6DN6 6JKJ 6JWM 6JWN 6KEY
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	Acetylcholine Receptor Activator Activity Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Innate Immune Response Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Chromatin Remodeling Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cellular Response To Oxygen-containing Compound Chromatin Organization Epigenetic Regulation Of Gene Expression Defense Response To Symbiont Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Defense Response To Other Organism Positive Regulation Of Interleukin-6 Production Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Defense Response To Gram-negative Bacterium Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Double-strand Break Repair GATOR1 Complex Binding Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of Establishment Of Blood-brain Barrier Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Peptidase Inhibitor Activity Growth Factor Receptor Binding
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