LAMP2 and UCHL1

Number of citations of the paper that reports this interaction (PMID 18550537)
39

Data Source:
HPRD (in vivo)

		LAMP2	UCHL1
Gene Name		lysosomal-associated membrane protein 2	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Late Endosome Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Enzyme Binding Protein Domain Specific Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	Platelet Degranulation Blood Coagulation Platelet Activation Protein Stabilization	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Protein Deubiquitination Sensory Perception Of Pain Axon Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		4 interactors: AP4M1 CTSA PIAS4 UCHL1	27 interactors: ADRA2A ADRA2B ADRA2C ADRB2 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PARK2 PLA2G2A RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		3920	7345
HPRD ID		02396	01877
Ensembl ID		ENSG00000005893	ENSG00000154277
Uniprot IDs		B7Z2R9 P13473	P09936
PDB IDs			2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Keratinocyte Apoptotic Process Axon Target Recognition Axon Transport Of Mitochondrion Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Receptor Transactivation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Norepinephrine Secretion Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Activation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorylation Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Phosphorylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Response To Abiotic Stimulus Negative Regulation Of Muscle Contraction Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERBB Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Response To Stimulus Positive Regulation Of Protein Metabolic Process
Tagcloud ?		albinism bloc colocalize confocal constituents disrupt disrupted encoded hair hypopigmentation localizations matp melanogenic melanosomal melanosomes misrouting oca oca2 oca4 oculocutaneous organelles pigmentation severely slc45a2 sorting subcellular trafficking transporters tyrosinase	1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax
Tagcloud (Difference) ?		albinism bloc colocalize confocal constituents disrupt disrupted encoded hair hypopigmentation localizations matp melanogenic melanosomal melanosomes misrouting oca oca2 oca4 oculocutaneous organelles pigmentation severely slc45a2 sorting subcellular trafficking transporters tyrosinase	1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax
Tagcloud (Intersection) ?