LAMP2 and UCHL1

Number of citations: 41 (PubMedID 18550537)
Data Source: HPRD (in vivo)

		LAMP2	UCHL1
Name		lysosomal associated membrane protein 2	ubiquitin C-terminal hydrolase L1
Structure
GO Annotations	Cellular Component	Autophagosome Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Perinuclear Region Of Cytoplasm Chaperone-mediated Autophagy Translocation Complex Extracellular Exosome Membrane Microdomain Ficolin-1-rich Granule Membrane	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding
	Biological Process	Protein Targeting Autophagy Lysosomal Lumen Acidification Cellular Response To Starvation Protein Import Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Lysosomal Lumen PH Elevation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Autophagosome Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Proton Transmembrane Transport Lysosomal Protein Catabolic Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus
Pathways		Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy	UCH proteinases
Drugs		None	Phenethyl Isothiocyanate
Diseases		Danon disease; X-linked vacuolar cardiomyopathy and myopathy	Parkinson's disease (PD)
GWAS		No GWAS studies recorded	Cognitive performance ( 19734545 ) Metabolite levels ( 23823483 )
Interacting Genes		6 interacting genes: AP4M1 APLNR CTSA PIAS4 SNCA UCHL1	30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28
Entrez ID		3920	7345
HPRD ID		02396	01877
Ensembl ID		ENSG00000005893	ENSG00000154277
Uniprot IDs		P13473	P09936 V9HW74
PDB IDs		2MOF 2MOM	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7
GO Terms Enriched among Interactors		Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mechanoreceptor Activity Apelin Receptor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Autophagy Enzyme Activator Activity Response To Desipramine Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Signal Transduction Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Negative Regulation Of Cell Communication Positive Regulation Of Calcium Ion Transport Apelin Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Autophagy Negative Regulation Of Protein Catabolic Process Lumenal Side Of Lysosomal Membrane Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Limb Epidermis Development Regulation Of Sequestering Of Calcium Ion Positive Regulation Of G Protein-coupled Receptor Internalization Establishment Of Localization In Cell Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Generation Of Precursor Metabolites And Energy Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation Protein Localization To Basolateral Plasma Membrane Regulation Of Calcium Ion Transmembrane Transport Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity