LAMP2 and AP4M1

Number of citations of the paper that reports this interaction (PubMedID 11139587)
0

Data Source:
HPRD (in vitro)

		LAMP2	AP4M1
Description		lysosomal associated membrane protein 2	adaptor related protein complex 4 subunit mu 1
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GO Annotations	Cellular Component	Autophagosome Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Perinuclear Region Of Cytoplasm Chaperone-mediated Autophagy Translocation Complex Extracellular Exosome Membrane Microdomain Ficolin-1-rich Granule Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding
	Biological Process	Protein Targeting Autophagy Lysosomal Lumen Acidification Cellular Response To Starvation Protein Import Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Lysosomal Lumen PH Elevation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Autophagosome Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Proton Transmembrane Transport Lysosomal Protein Catabolic Process	Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane
Pathways		Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy	Lysosome Vesicle Biogenesis
Drugs
Diseases		Danon disease; X-linked vacuolar cardiomyopathy and myopathy	Cerebral palsy
GWAS			Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: AP4M1 APLNR CTSA PIAS4 SNCA UCHL1	16 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 TGOLN2 USP47 ZBTB22
Entrez ID		3920	9179
HPRD ID		02396	03803
Ensembl ID		ENSG00000005893	ENSG00000221838
Uniprot IDs		P13473	C9JC87 C9JWL4 H7C0A0 O00189
PDB IDs		2MOF 2MOM	3L81 4MDR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mechanoreceptor Activity Apelin Receptor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Autophagy Enzyme Activator Activity Response To Desipramine Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Signal Transduction Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Negative Regulation Of Cell Communication Positive Regulation Of Calcium Ion Transport Apelin Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Autophagy Negative Regulation Of Protein Catabolic Process Lumenal Side Of Lysosomal Membrane Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Limb Epidermis Development Regulation Of Sequestering Of Calcium Ion Positive Regulation Of G Protein-coupled Receptor Internalization Establishment Of Localization In Cell Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Generation Of Precursor Metabolites And Energy Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation Protein Localization To Basolateral Plasma Membrane Regulation Of Calcium Ion Transmembrane Transport Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex	Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization
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