LAMP2

Description		lysosomal associated membrane protein 2
Image
GO Annotations	Cellular Component	Autophagosome Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Perinuclear Region Of Cytoplasm Chaperone-mediated Autophagy Translocation Complex Extracellular Exosome Membrane Microdomain Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity
	Biological Process	Protein Targeting Autophagy Lysosomal Lumen Acidification Cellular Response To Starvation Protein Import Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Lysosomal Lumen PH Elevation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Autophagosome Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Proton Transmembrane Transport Lysosomal Protein Catabolic Process
Pathways		Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy
Drugs
Diseases		Danon disease; X-linked vacuolar cardiomyopathy and myopathy
GWAS
Interacting Genes		6 interacting genes: AP4M1 APLNR CTSA PIAS4 SNCA UCHL1
Entrez ID		3920
HPRD ID		02396
Ensembl ID		ENSG00000005893
Uniprot IDs		P13473
PDB IDs		2MOF 2MOM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mechanoreceptor Activity Apelin Receptor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Autophagy Enzyme Activator Activity Response To Desipramine Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Signal Transduction Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Negative Regulation Of Cell Communication Positive Regulation Of Calcium Ion Transport Apelin Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Autophagy Negative Regulation Of Protein Catabolic Process Lumenal Side Of Lysosomal Membrane Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Limb Epidermis Development Regulation Of Sequestering Of Calcium Ion Positive Regulation Of G Protein-coupled Receptor Internalization Establishment Of Localization In Cell Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Generation Of Precursor Metabolites And Energy Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation Protein Localization To Basolateral Plasma Membrane Regulation Of Calcium Ion Transmembrane Transport Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex
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