IQGAP2 and ACTR2

Number of citations of the paper that reports this interaction (PMID 12515716)
11

Data Source:
HPRD (in vivo)

		IQGAP2	ACTR2
Gene Name		IQ motif containing GTPase activating protein 2	ARP2 actin-related protein 2 homolog (yeast)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Filamentous Actin Extracellular Vesicular Exosome	Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Actin Cap Cell Projection Extracellular Vesicular Exosome
	Molecular Function	Actin Binding GTPase Inhibitor Activity Ras GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Catalytic Activity Thrombin Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Establishment Or Maintenance Of Cell Polarity Axon Guidance Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytoplasmic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cilium Assembly Innate Immune Response Ephrin Receptor Signaling Pathway Spindle Localization
Pathways			EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Hearing impairment ( 20068591) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		5 interactors: ACTR2 CALM1 CDC42 RAC1 RHOG	13 interactors: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 CTTN ELF5 HCLS1 IQGAP2 WASF1 WASF2 WASL
Entrez ID		10788	10097
HPRD ID		09253	05023
Ensembl ID		ENSG00000145703	ENSG00000138071
Uniprot IDs			P61160
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Assembly Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Response To External Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Platelet Activation Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis Neuron Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Neuron Differentiation Cytoskeleton Organization Regulation Of Protein Complex Assembly Cell Projection Organization Locomotion Immune Response	Actin Filament Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Positive Regulation Of Organelle Organization Cytoskeleton Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Regulation Of Organelle Organization Arp2/3 Complex-mediated Actin Nucleation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Actin Nucleation Regulation Of Cellular Component Organization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Positive Regulation Of Protein Complex Assembly Actin Polymerization Or Depolymerization Actin Filament Polymerization Movement Of Cell Or Subcellular Component Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Ephrin Receptor Signaling Pathway Protein Polymerization Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Endocytosis Cell Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Development Cell Projection Morphogenesis Cell Part Morphogenesis Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process System Development Actin Filament-based Movement Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Morphogenesis Positive Regulation Of Immune Response
Tagcloud ?		293t androgen bph cadherin candidate collectively concept du145 ectopic glands gleason hepatocellular intraepithelial lncap mechanistically neoplasia pc pc3 pcs pin prostate prostatic substantially suppress suppresses tumorigenesis tumorigenic tumours xenograft
Tagcloud (Difference) ?		293t androgen bph cadherin candidate collectively concept du145 ectopic glands gleason hepatocellular intraepithelial lncap mechanistically neoplasia pc pc3 pcs pin prostate prostatic substantially suppress suppresses tumorigenesis tumorigenic tumours xenograft
Tagcloud (Intersection) ?