IQGAP2

Gene Name		IQ motif containing GTPase activating protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Microtubule Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Filamentous Actin Extracellular Vesicular Exosome
	Molecular Function	Actin Binding GTPase Inhibitor Activity Ras GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Catalytic Activity Thrombin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Hearing impairment ( 20068591) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-protein Interactions		5 interactors: ACTR2 CALM1 CDC42 RAC1 RHOG
Entrez ID		10788
HPRD ID		09253
Ensembl ID		ENSG00000145703
Uniprot IDs
PDB IDs
Enriched GO Terms of Interacting Partners?		Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Projection Assembly Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Response To External Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Cell Morphogenesis Involved In Differentiation Platelet Activation Innate Immune Response Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Phagocytosis Neuron Development Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Actin Filament Organization Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Neuron Differentiation Cytoskeleton Organization Regulation Of Protein Complex Assembly Cell Projection Organization Locomotion Immune Response
Tagcloud ?		293t androgen bph cadherin candidate collectively concept du145 ectopic glands gleason hepatocellular intraepithelial lncap mechanistically neoplasia pc pc3 pcs pin prostate prostatic substantially suppress suppresses tumorigenesis tumorigenic tumours xenograft