IQGAP2

Description		IQ motif containing GTPase activating protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Plasma Membrane Microvillus Cell Cortex Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Cell Leading Edge Extracellular Exosome Plasma Membrane Bounded Cell Projection
	Molecular Function	Actin Binding GTPase Inhibitor Activity GTPase Activator Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Small GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Signal Transduction Regulation Of Actin Cytoskeleton Organization Arp2/3 Complex-mediated Actin Nucleation Thrombin-activated Receptor Signaling Pathway Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization
Pathways		RHO GTPases activate IQGAPs Neutrophil degranulation CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Late-onset Alzheimer's disease ( 27770636) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Novel Interacting Genes		1 novel interacting genes: ALG8
Interacting Genes		5 interacting genes: ACTR2 CALM1 CDC42 RAC1 RHOG
Entrez ID		10788
HPRD ID		09253
Ensembl ID		ENSG00000145703
Uniprot IDs		B7Z7U6 B7Z7X2 F5H7S7 Q13576 Q59HA3
PDB IDs		3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Organization Actin Filament Organization Cellular Response To Type II Interferon G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Actin Cytoskeleton Organization Response To Type II Interferon Actin Filament-based Process Thioesterase Binding Focal Adhesion Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Postsynapse Organization Cell Projection GTP-dependent Protein Binding Cytoskeleton Regulation Of Plasma Membrane Bounded Cell Projection Organization Rac Protein Signal Transduction Regulation Of Cell Projection Organization Regulation Of Ruffle Assembly Phagocytosis, Engulfment Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Postsynapse Assembly Substantia Nigra Development Cortical Cytoskeleton Organization Regulation Of Synapse Organization Membrane Invagination GTPase Activity Non-canonical Wnt Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Actin Cytoskeleton Organization Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Endoplasmic Reticulum Membrane GTP Binding Cell Projection Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Regulation Of Actin Filament-based Process
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