ANK2 and OBSCN

Number of citations of the paper that reports this interaction (PubMedID 12527750)
38

Data Source:
HPRD (in vitro)

		ANK2	OBSCN
Description		ankyrin 2	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Synapse Postsynaptic Membrane Recycling Endosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Myofibril Z Disc M Band Sarcolemma
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding ATPase Binding Channel Activator Activity Potassium Channel Activator Activity Phosphorylation-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Kinase Activity Transferase Activity Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Intracellular Calcium Ion Homeostasis Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Cell Surface Protein Localization To M-band Protein Localization To T-tubule Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Import Across Plasma Membrane	Cell Differentiation Protein Localization To M-band Sarcomere Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)
Interacting Genes		21 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN RIPK4 SIGMAR1 SPTBN1 TAF9 TNIK TP53	8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN
Entrez ID		287	84033
HPRD ID		00110	10551
Ensembl ID		ENSG00000145362	ENSG00000154358
Uniprot IDs		A0A5F9ZGS5 A0A5F9ZGY1 A0A5F9ZGZ1 A0A5F9ZH03 A0A5F9ZH10 A0A5F9ZH17 A0A5F9ZH18 A0A5F9ZH34 A0A5F9ZH39 A0A5F9ZH58 A0A5F9ZH70 A0A5F9ZH99 A0A5F9ZHE2 A0A5F9ZHJ4 A0A5F9ZHJ6 A0A5F9ZHL3 A0A5F9ZHL9 A0A5F9ZHN0 A0A5F9ZHQ3 A0A5F9ZHR2 A0A5F9ZHY6 A0A5F9ZI08 A0A5F9ZI16 A0A5F9ZI36 A0A5F9ZI53 A0A5F9ZI56 A0A5F9ZI69 A0A5F9ZI81 E9PCH6 H0Y933 Q01484	A6NGQ3
PDB IDs		4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q 8ZE8
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Autophagosome Maturation Autophagosome Membrane Phospholipid Binding Autophagosome Macroautophagy Autophagosome Assembly Cellular Response To Starvation Autophagosome Organization Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Vacuole Organization Beta-tubulin Binding Cytoskeleton GABA Receptor Binding Response To Nutrient Levels Ankyrin Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Cellular Component Assembly Cellular Response To Stress Organelle Organization Microtubule Binding Organelle Membrane Cytosol Glutamatergic Synapse ATPase Binding System Development Organelle Assembly Protein-folding Chaperone Binding Endomembrane System M Band Response To Stress Cortical Cytoskeleton Negative Regulation Of Proteolysis Regulation Of ATP-dependent Activity Central Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cytoskeleton Organization Microtubule Associated Complex Regulation Of Proteolysis Cytoplasm Negative Regulation Of Helicase Activity	M Band Transmembrane Transporter Binding Enzyme Binding Z Disc A Band Actin-myosin Filament Sliding Muscle Filament Sliding Cytoskeletal Anchor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Spectrin Binding Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Actin-mediated Cell Contraction Condensed Nuclear Chromosome Protein-containing Complex Sarcomere Regulation Of Action Potential Actin Filament-based Movement Protein Localization To T-tubule Structural Constituent Of Cytoskeleton ATPase Binding Protein Kinase Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Localization To M-band Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Atrial Cardiac Muscle Cell To AV Node Cell Communication Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Regulation Of Heart Rate Sarcolemma Skeletal Muscle Myosin Thick Filament Assembly Regulation Of Sequestering Of Calcium Ion Maintenance Of Epithelial Cell Apical/basal Polarity Structural Molecule Activity Ankyrin-1 Complex Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Atrial Cardiac Muscle Cell Action Potential Potassium Channel Activator Activity Calcium-mediated Signaling SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication
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