ANK2 and EPB42

Number of citations of the paper that reports this interaction (PubMedID 2968981)
0

Data Source:
BioGRID (pull down)

		ANK2	EPB42
Description		ankyrin 2	erythrocyte membrane protein band 4.2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Synapse Postsynaptic Membrane Recycling Endosome	Cytoplasm Cytoskeleton Plasma Membrane Membrane Cortical Cytoskeleton Cell Periphery Ankyrin-1 Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding ATPase Binding Channel Activator Activity Potassium Channel Activator Activity Phosphorylation-dependent Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Structural Constituent Of Cytoskeleton Protein Binding ATP Binding
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Intracellular Calcium Ion Homeostasis Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Cell Surface Protein Localization To M-band Protein Localization To T-tubule Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Import Across Plasma Membrane	Cell Morphogenesis Cytoskeleton Organization Regulation Of Cell Shape Hemoglobin Metabolic Process Erythrocyte Maturation Spleen Development Monoatomic Ion Homeostasis Multicellular Organismal-level Iron Ion Homeostasis
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Hereditary spherocytosis (SPH)
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		21 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN RIPK4 SIGMAR1 SPTBN1 TAF9 TNIK TP53	13 interacting genes: ANK1 ANK2 BLOC1S4 CD47 DMTN EPB41 KRAS MAPK14 SLC4A1 SLC4A2 SPINK7 SPTAN1 STX12
Entrez ID		287	2038
HPRD ID		00110	01517
Ensembl ID		ENSG00000145362	ENSG00000166947
Uniprot IDs		A0A5F9ZGS5 A0A5F9ZGY1 A0A5F9ZGZ1 A0A5F9ZH03 A0A5F9ZH10 A0A5F9ZH17 A0A5F9ZH18 A0A5F9ZH34 A0A5F9ZH39 A0A5F9ZH58 A0A5F9ZH70 A0A5F9ZH99 A0A5F9ZHE2 A0A5F9ZHJ4 A0A5F9ZHJ6 A0A5F9ZHL3 A0A5F9ZHL9 A0A5F9ZHN0 A0A5F9ZHQ3 A0A5F9ZHR2 A0A5F9ZHY6 A0A5F9ZI08 A0A5F9ZI16 A0A5F9ZI36 A0A5F9ZI53 A0A5F9ZI56 A0A5F9ZI69 A0A5F9ZI81 E9PCH6 H0Y933 Q01484	P16452
PDB IDs		4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q 8ZE8	7TVZ 7TW0 7TW1 7TW3 7TW5 7TW6 7UZS 7V0K 7V0Q 8CS9 8CSL 8CSW 8CTE
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Autophagosome Maturation Autophagosome Membrane Phospholipid Binding Autophagosome Macroautophagy Autophagosome Assembly Cellular Response To Starvation Autophagosome Organization Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Vacuole Organization Beta-tubulin Binding Cytoskeleton GABA Receptor Binding Response To Nutrient Levels Ankyrin Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Cellular Component Assembly Cellular Response To Stress Organelle Organization Microtubule Binding Organelle Membrane Cytosol Glutamatergic Synapse ATPase Binding System Development Organelle Assembly Protein-folding Chaperone Binding Endomembrane System M Band Response To Stress Cortical Cytoskeleton Negative Regulation Of Proteolysis Regulation Of ATP-dependent Activity Central Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cytoskeleton Organization Microtubule Associated Complex Regulation Of Proteolysis Cytoplasm Negative Regulation Of Helicase Activity	Spectrin Binding Spectrin-associated Cytoskeleton Structural Constituent Of Cytoskeleton Basolateral Plasma Membrane Cortical Cytoskeleton Regulation Of Actin Filament-based Process Ankyrin-1 Complex Monoatomic Anion Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Solute:inorganic Anion Antiporter Activity Cytoskeleton Organization A Band BLOC-1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of Actin Cytoskeleton Organization Z Disc Cytoskeletal Anchor Activity Actin Cytoskeleton Organization Organelle Organization Enzyme Binding M Band Intracellular Monoatomic Ion Homeostasis Regulation Of Biological Quality Intracellular Monoatomic Cation Homeostasis Homeostatic Process Actin Filament-based Process Bicarbonate Transport Erythrocyte Development Actin Filament Capping Protein-membrane Adaptor Activity Monoatomic Cation Homeostasis Protein Localization To Plasma Membrane Monoatomic Ion Homeostasis Negative Regulation Of Actin Filament Depolymerization Localization Within Membrane Intracellular Chemical Homeostasis Regulation Of Cytoskeleton Organization Osteoclast Differentiation Protein Localization To Cell Periphery Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Protein Localization To T-tubule PH Elevation Regulation Of Actin Filament Organization Endomembrane System Cellular Homeostasis Regulation Of Interleukin-12 Production Myeloid Cell Development Cytoskeletal Protein Binding Regulation Of Organelle Organization
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