ANK2 and SPTBN1

Number of citations of the paper that reports this interaction (PMID 15262991)
32

Data Source:
HPRD (two hybrid)

		ANK2	SPTBN1
Gene Name		ankyrin 2, neuronal	spectrin, beta, non-erythrocytic 1
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein Complex Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity	Mitotic Cytokinesis Plasma Membrane Organization Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Targeting To Plasma Membrane
Pathways		Interaction between L1 and Ankyrins Axon guidance L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance Nephrin interactions L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)	Bone mineral density ( 22504420) Bone mineral density (spine) ( 19079262 19801982 18445777) Myopia (pathological) ( 22685421)
Protein-Protein Interactions		12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53	39 interactors: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 CPNE1 CPNE4 CSNK2A1 CTNNA1 DISC1 EPB41 EPB41L3 GRB2 GRIA2 MAPK14 MEF2C NF2 PACSIN1 PDE4D PJA1 PLCB1 PLEKHA5 PRKACA PYGO1 RINT1 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 TNIK TRAF3IP1 YWHAG ZNF512B
Entrez ID		287	6711
HPRD ID		00110	01683
Ensembl ID		ENSG00000145362	ENSG00000115306
Uniprot IDs		Q01484	B2ZZ89 Q01082
PDB IDs		4D8O	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation	Regulation Of Cellular Component Organization System Development Intracellular Signal Transduction Nervous System Development Regulation Of Cellular Localization Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Phosphorylation Regulation Of Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell-cell Junction Organization Regulation Of Intracellular Transport Developmental Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Neurogenesis Negative Regulation Of Phosphorylation Apoptotic Process Signaling Anatomical Structure Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Development Organelle Organization Programmed Cell Death Cell Communication Generation Of Neurons Kidney Development Cell Death Cell Morphogenesis Death Regulation Of Protein Metabolic Process Cell-cell Junction Assembly Epithelium Development Cellular Response To Organonitrogen Compound Renal System Development Cell Activation Organ Development Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Cell Projection Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Neuron Development
Tagcloud ?		absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Difference) ?		absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses	adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco
Tagcloud (Intersection) ?