ANK2 and MAP1LC3C

Number of citations of the paper that reports this interaction (PubMedID 29867141)
0

Data Source:
BioGRID (pull down)

		ANK2	MAP1LC3C
Description		ankyrin 2	microtubule associated protein 1 light chain 3 gamma
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Synapse Postsynaptic Membrane Recycling Endosome	Autophagosome Membrane Cytoplasm Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Anchor Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding ATPase Binding Channel Activator Activity Potassium Channel Activator Activity Phosphorylation-dependent Protein Binding	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Intracellular Calcium Ion Homeostasis Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Intracellular Protein Localization Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Cell Surface Protein Localization To M-band Protein Localization To T-tubule Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Import Across Plasma Membrane	Autophagosome Assembly Mitophagy Autophagy Response To Stress Cellular Response To Nitrogen Starvation Cellular Response To Starvation Macroautophagy Protein Exit From Endoplasmic Reticulum Aggrephagy Autophagosome Maturation
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport	Macroautophagy
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Coprococcus) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Parkinson's disease ( 28892059) Periventricular white matter hyperintensities ( 32517579) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483)
Interacting Genes		21 interacting genes: ANKRD28 DNAJB1 DNAJB5 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN RIPK4 SIGMAR1 SPTBN1 TAF9 TNIK TP53	41 interacting genes: AMBRA1 ANK2 ANK3 APPL1 ATG13 ATXN3 BICC1 CALCOCO2 CAPN3 CDC37 CUL3 GMEB2 IRGM KBTBD6 KBTBD7 LAT LMNB1 MEFV MISP NCOR1 NEDD4 NIPBL OPRM1 OPTN PDLIM1 RESF1 RHOXF1 RUFY4 SAMM50 STK3 TAX1BP1 TBC1D25 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 TSR2 WDFY3 WDR81 ZNF24
Entrez ID		287	440738
HPRD ID		00110	14226
Ensembl ID		ENSG00000145362	ENSG00000197769
Uniprot IDs		A0A5F9ZGS5 A0A5F9ZGY1 A0A5F9ZGZ1 A0A5F9ZH03 A0A5F9ZH10 A0A5F9ZH17 A0A5F9ZH18 A0A5F9ZH34 A0A5F9ZH39 A0A5F9ZH58 A0A5F9ZH70 A0A5F9ZH99 A0A5F9ZHE2 A0A5F9ZHJ4 A0A5F9ZHJ6 A0A5F9ZHL3 A0A5F9ZHL9 A0A5F9ZHN0 A0A5F9ZHQ3 A0A5F9ZHR2 A0A5F9ZHY6 A0A5F9ZI08 A0A5F9ZI16 A0A5F9ZI36 A0A5F9ZI53 A0A5F9ZI56 A0A5F9ZI69 A0A5F9ZI81 E9PCH6 H0Y933 Q01484	Q9BXW4
PDB IDs		4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS 6KZJ 6M3Q 8ZE8	2NCN 3VVW 3WAM 3WAP 5DPW
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Autophagosome Maturation Autophagosome Membrane Phospholipid Binding Autophagosome Macroautophagy Autophagosome Assembly Cellular Response To Starvation Autophagosome Organization Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Autophagy Ubiquitin Protein Ligase Binding Vacuole Organization Beta-tubulin Binding Cytoskeleton GABA Receptor Binding Response To Nutrient Levels Ankyrin Binding Protein-containing Complex Organization Microtubule Cytoplasmic Vesicle Cellular Component Assembly Cellular Response To Stress Organelle Organization Microtubule Binding Organelle Membrane Cytosol Glutamatergic Synapse ATPase Binding System Development Organelle Assembly Protein-folding Chaperone Binding Endomembrane System M Band Response To Stress Cortical Cytoskeleton Negative Regulation Of Proteolysis Regulation Of ATP-dependent Activity Central Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cytoskeleton Organization Microtubule Associated Complex Regulation Of Proteolysis Cytoplasm Negative Regulation Of Helicase Activity	Autophagosome Positive Regulation Of Autophagy Regulation Of Autophagy Autophagy Positive Regulation Of Catabolic Process Regulation Of Macroautophagy Catabolic Process Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Protein Polyubiquitination Vacuole Organization Protein K48-linked Ubiquitination Regulation Of Intracellular Signal Transduction Cytosol Organelle Organization Regulation Of Cell Communication Cytoplasmic Vesicle Regulation Of Innate Immune Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Localization To Organelle Macroautophagy Regulation Of Protein Stability Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Innate Immune Response-activating Signaling Pathway Organelle Assembly Ubiquitin-dependent Protein Catabolic Process Protein Localization To Phagocytic Vesicle Regulation Of Autophagosome Maturation Modification-dependent Protein Catabolic Process Cytoplasm Regulation Of Gene Expression Intracellular Protein Localization Regulation Of Macromolecule Metabolic Process Suppression Of Viral Release By Host Autophagosome Membrane Regulation Of Signaling Activation Of Innate Immune Response Protein Monoubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Macromolecule Biosynthetic Process Protein-macromolecule Adaptor Activity
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