MAFA and PDX1

Number of citations of the paper that reports this interaction (PMID 15664999)
50

Data Source:
HPRD (in vivo, in vitro)

		MAFA	PDX1
Gene Name		v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	pancreatic and duodenal homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nitric Oxide Mediated Signal Transduction Response To Glucose Insulin Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Endocrine Pancreas Development Organ Regeneration Positive Regulation Of Insulin Secretion Response To Vitamin Response To Cytokine Response To Nicotine Response To Drug Glucose Homeostasis Response To Leucine Positive Regulation Of DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Fasting glucose-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		5 interactors: MAF MAPK1 MAPK14 NEUROD1 PDX1	13 interactors: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		389692	3651
HPRD ID		14346	02843
Ensembl ID		ENSG00000182759	ENSG00000139515
Uniprot IDs		Q8NHW3	P52945
PDB IDs		4EOT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Development Nitric Oxide Mediated Signal Transduction Transcription, DNA-templated Enteroendocrine Cell Differentiation RNA Biosynthetic Process Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization Epithelium Development Positive Regulation Of DNA Binding Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Insulin Secretion Organ Development Glandular Epithelial Cell Differentiation RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Endocrine Pancreas Development Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Peptide Hormone Secretion Toll-like Receptor 3 Signaling Pathway Peptide Secretion Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Epithelial Cell Differentiation Hormone Secretion Regulation Of DNA Binding Regulation Of Intracellular Signal Transduction Hormone Transport Peptide Transport Pancreas Development Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Double-strand Break Repair Via Nonhomologous End Joining Organ Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Hyperosmotic Salinity Response Positive Regulation Of Gene Expression V(D)J Recombination Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Head Development Cellular Response To X-ray Endocrine Pancreas Development Immunoglobulin V(D)J Recombination System Development DNA Recombination Central Nervous System Development Transcription, DNA-templated Regulation Of Cell Differentiation Establishment Of Integrated Proviral Latency Anterior/posterior Pattern Specification RNA Biosynthetic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Telomere Maintenance Positive Regulation Of Type I Interferon Production B Cell Lineage Commitment Establishment Of Viral Latency Positive Regulation Of Cellular Metabolic Process Cellular Response To Salt Stress Multicellular Organismal Development Pancreas Development Anatomical Structure Development Immune System Development Regulation Of Neurogenesis Regulation Of Type I Interferon Production Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Innate Immune Response Regulation Of Protein Stability Immune System Process Positive Regulation Of Neurogenesis Regulation Of Cell Development Positive Regulation Of Cell Differentiation Response To Ionizing Radiation Developmental Process Double-strand Break Repair Transcription From RNA Polymerase II Promoter Hyperosmotic Response
Tagcloud ?		2h3 antisense attaining bonds capable cdna cloned clustering conservation cysteinyl deduced disulfide epsilon fc g63 glycoprotein homology immunomodulatory intrachain lectin mast named novo oligonucleotides rbl ri secretory stimulus though	ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors
Tagcloud (Difference) ?		2h3 antisense attaining bonds capable cdna cloned clustering conservation cysteinyl deduced disulfide epsilon fc g63 glycoprotein homology immunomodulatory intrachain lectin mast named novo oligonucleotides rbl ri secretory stimulus though	ablate ablated adenoviral carry cycles ductal ganciclovir gcv implants intraperitoneal ip iv liposomal longest microg minimal monitored panc pancreatic pdac repeated scid superior suppresses survived thymidine tk toxicity vectors
Tagcloud (Intersection) ?