MAFA and HERC4

Number of citations of the paper that reports this interaction (PubMedID 37028761)
27

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MAFA	HERC4
Description		MAF bZIP transcription factor A	HECT and RLD domain containing E3 ubiquitin protein ligase 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Fibrillar Center Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Glucose Insulin Secretion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Protein Ubiquitination Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway
Pathways		Regulation of gene expression in beta cells	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Nonsyndromic cleft palate ( 31609978)	Appendicular lean mass ( 33097823) Body mass index ( 28892062)
Interacting Genes		6 interacting genes: HERC4 MAF MAPK1 MAPK14 NEUROD1 PDX1	7 interacting genes: HERC6 MAFA UBC UBE2D2 UBE2E3 UBE2J2 UBE2L3
Entrez ID		389692	26091
HPRD ID		14346	13646
Ensembl ID		ENSG00000182759	ENSG00000148634
Uniprot IDs		Q8NHW3	Q5GLZ8
PDB IDs		4EOT
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase II Negative Regulation Of Type B Pancreatic Cell Apoptotic Process DNA-templated Transcription Cell Differentiation Response To Nutrient Levels Enteroendocrine Cell Differentiation MAP Kinase Activity Endocrine Pancreas Development Cellular Developmental Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Protein Transport Response To Lipid Lipopolysaccharide-mediated Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Insulin Secretion Positive Regulation Of Establishment Of Protein Localization Regulation Of Epithelial Cell Apoptotic Process Inner Ear Development Epithelial Cell Differentiation Peptide Hormone Secretion Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Acadesine Embryonic Morphogenesis Sequence-specific DNA Binding Positive Regulation Of Insulin Secretion DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Peptide Secretion Regulation Of Ossification Regulation Of Cellular Localization Stem Cell Differentiation Animal Organ Development Homeostatic Process Regulation Of Establishment Of Protein Localization Anatomical Structure Morphogenesis Ficolin-1-rich Granule Lumen Negative Regulation Of Signaling Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Response To Peptide Response To Tumor Necrosis Factor RNA Metabolic Process Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Protein Modification Process Macromolecule Catabolic Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Transferase Activity Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex ATP Binding Macromolecule Metabolic Process Nucleotide Binding Ubiquitin-protein Transferase Activator Activity Cytosol Protein Tag Activity Positive Regulation Of Establishment Of Protein Localization Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Activity Nucleoplasm
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