MAFA and NEUROD1

Number of citations of the paper that reports this interaction (PMID 15665000)
48

Data Source:
HPRD (in vivo, in vitro)

		MAFA	NEUROD1
Gene Name		v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	neuronal differentiation 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nitric Oxide Mediated Signal Transduction Response To Glucose Insulin Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter	Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Transcription, DNA-templated Nucleocytoplasmic Transport Nitric Oxide Mediated Signal Transduction Response To Glucose Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebellum Development Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Endocrine Pancreas Development Amacrine Cell Differentiation Enteroendocrine Cell Differentiation Response To Drug Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of JAK-STAT Cascade Embryonic Organ Morphogenesis Inner Ear Development Regulation Of Insulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Intestinal Epithelial Structure Maintenance Regulation Of Cell Cycle Arrest Cellular Response To Glucose Stimulus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Regulation of beta-cell development Regulation of gene expression in beta cells	Regulation of beta-cell development Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Regulation of gene expression in beta cells
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: MAF MAPK1 MAPK14 NEUROD1 PDX1	12 interactors: CALM1 CALM2 CALM3 DUSP3 EP300 HAP1 MAFA MAP3K10 PDX1 PITX1 RREB1 TCF4
Entrez ID		389692	4760
HPRD ID		14346	03428
Ensembl ID		ENSG00000182759	ENSG00000162992
Uniprot IDs		Q8NHW3	Q13562
PDB IDs		4EOT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Tissue Development Nitric Oxide Mediated Signal Transduction Transcription, DNA-templated Enteroendocrine Cell Differentiation RNA Biosynthetic Process Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization Epithelium Development Positive Regulation Of DNA Binding Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Insulin Secretion Organ Development Glandular Epithelial Cell Differentiation RNA Metabolic Process Toll-like Receptor 5 Signaling Pathway Endocrine Pancreas Development Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Peptide Hormone Secretion Toll-like Receptor 3 Signaling Pathway Peptide Secretion Cellular Macromolecule Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Cell Differentiation Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Epithelial Cell Differentiation Hormone Secretion Regulation Of DNA Binding Regulation Of Intracellular Signal Transduction Hormone Transport Peptide Transport Pancreas Development Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cation Channel Activity Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cellular Biosynthetic Process Second-messenger-mediated Signaling Positive Regulation Of Metabolic Process Glucose Metabolic Process Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Metabolic Process Intracellular Signal Transduction Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transport Neurotrophin Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Secretion By Cell Positive Regulation Of Nitric-oxide Synthase Activity Cell Surface Receptor Signaling Pathway Monosaccharide Metabolic Process Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Glycogen Catabolic Process Positive Regulation Of Calcium Ion Transport Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Voltage-gated Calcium Channel Activity Central Nervous System Development Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Response To Stress Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Organic Substance
Tagcloud ?		2h3 antisense attaining bonds capable cdna cloned clustering conservation cysteinyl deduced disulfide epsilon fc g63 glycoprotein homology immunomodulatory intrachain lectin mast named novo oligonucleotides rbl ri secretory stimulus though	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Difference) ?		2h3 antisense attaining bonds capable cdna cloned clustering conservation cysteinyl deduced disulfide epsilon fc g63 glycoprotein homology immunomodulatory intrachain lectin mast named novo oligonucleotides rbl ri secretory stimulus though	aa ad1 ad2 beta2 carboxy cbp chimeras coactivator constructs convert creb ectoderm ectopic embryos evolutionarily gal4 helix implicate islet morphogenesis precursors premature separable spanning transactivation utilized xenopus
Tagcloud (Intersection) ?