KRT35 and ABI3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT35	ABI3
Description		keratin 35	ABI family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Cytoplasm Postsynaptic Density Membrane Lamellipodium SCAR Complex Dendritic Spine Dendritic Shaft Postsynapse Actin-based Cell Projection Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Signaling Adaptor Activity Identical Protein Binding Actin Filament Binding
	Biological Process	Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis Epithelial Cell Differentiation Intermediate Filament Organization	Neuron Migration Defense Response To Tumor Cell Negative Regulation Of Lamellipodium Assembly Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Regulation Of Cell Migration Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Postsynaptic Density Assembly Negative Regulation Of Ruffle Assembly Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cellular Senescence
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Asthma ( 31619474) Family history of Alzheimer's disease ( 30617256) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		88 interacting genes: ABI3 AIRIM ATG9A BCAS2 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446	77 interacting genes: ABI2 ABI3BP ACTN3 AGTR1 ARHGAP9 ARMC7 BAIAP2L2 BFSP2 BLOC1S5 CENPQ CEP170P1 CEP44 CYFIP2 DESI1 DTNB DTNBP1 EIF3H EIF3M EMILIN1 ENAH EVL FAM124B FARSA FBF1 GNG13 GOLM1 GRB2 HOMER1 HOMER2 HOMER3 IFT20 IHO1 KANK2 KIAA0408 KIFC3 KLC3 KLC4 KRT13 KRT14 KRT15 KRT24 KRT28 KRT31 KRT35 KRT36 KRT38 MAGEA12 MED29 MIS18A MRFAP1 MRFAP1L1 NCK2 NDEL1 NHSL2 NUP58 OIP5 PAK1 PAK2 PSMA1 RUFY3 RUNX1T1 SH3BP1 SMARCD1 SNAP23 SOS1 STX1A STX2 SUFU TMEM147 TRAF4 TXN2 VARS2 VASP WAS WASF1 WASF2 WASHC1
Entrez ID		3886	51225
HPRD ID		04138	05900
Ensembl ID		ENSG00000197079	ENSG00000108798
Uniprot IDs		Q92764	Q9P2A4
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope Negative Regulation Of Cilium Assembly Regulation Of Organelle Assembly Extracellular Exosome	Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Actin Filament Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Keratin Filament Regulation Of Actin Cytoskeleton Organization Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Structural Molecule Activity SH3 Domain Binding Anatomical Structure Morphogenesis Morphogenesis Of An Epithelium Intermediate Filament Cytoskeleton Organization Regulation Of Cytoskeleton Organization Lamellipodium Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Actin Filament Organization Tissue Morphogenesis Positive Regulation Of Supramolecular Fiber Organization G Protein-coupled Glutamate Receptor Binding SCAR Complex Positive Regulation Of Cytoskeleton Organization Organelle Organization Actin Polymerization Or Depolymerization Cytosol Regulation Of Actin Filament Polymerization Epithelial Cell Differentiation Anchoring Junction Regulation Of Cellular Component Size Protein Binding Positive Regulation Of Protein Polymerization Positive Regulation Of Actin Filament Polymerization Cellular Component Assembly Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Profilin Binding Developmental Process Regulation Of Organelle Organization Regulation Of Actin Nucleation Postsynaptic Density Vesicle Membrane Cell Projection Organization Positive Regulation Of Actin Nucleation Regulation Of Store-operated Calcium Entry
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