KRT35 and EFCAB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT35	EFCAB3
Description		keratin 35	EF-hand calcium binding domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Calcium Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS			Objective response to lithium treatment ( 26503763)
Interacting Genes		88 interacting genes: ABI3 AIRIM ATG9A BCAS2 C21orf58 CCDC120 CCDC185 CCDC196 CCHCR1 CD33 CTSZ DMRT3 DTNB EFCAB3 ENKD1 EXOSC5 FAM221B FRS3 HAPLN2 HCK HDAC4 HGS HOXA1 HOXC8 KCTD9 KDM1A KIFC3 KLHL38 KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LENG1 LGALS14 LONRF1 MAPKBP1 MCRS1 MYO15B OIP5 OTX1 PKN1 POU4F2 PRPF18 PRPF31 PRR35 RUNX1T1 SCNM1 SHC3 SLC43A2 SMARCE1 SMYD1 TAPBPL TBC1D21 TBC1D30 TBC1D7 TCEANC TCHP TEKT4 TEPSIN TLE5 TRIM29 TSG101 TXLNA TXLNB UBASH3A USP2 VPS9D1 ZNF417 ZNF446	9 interacting genes: CBY2 GPRASP2 HPRT1 KRT34 KRT35 OXER1 SPECC1L TTC23 WWP2
Entrez ID		3886	146779
HPRD ID		04138	08077
Ensembl ID		ENSG00000197079	ENSG00000172421
Uniprot IDs		Q92764	Q8N7B9
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Epidermis Development Intermediate Filament Cytoskeleton Cornified Envelope Negative Regulation Of Cilium Assembly Regulation Of Organelle Assembly Extracellular Exosome	Guanine Salvage Hypoxanthine Salvage Hypoxanthine Phosphoribosyltransferase Activity Guanine Phosphoribosyltransferase Activity Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Neural Crest Cell Delamination 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Adenine Metabolic Process Hypoxanthine Biosynthetic Process Hypoxanthine Metabolic Process Anterior Neural Tube Closure Guanine Metabolic Process GMP Salvage GMP Catabolic Process IMP Salvage Positive Regulation Of Dopamine Metabolic Process AMP Salvage Intermediate Filament Negative Regulation Of Potassium Ion Export Across Plasma Membrane Purine Ribonucleoside Salvage Structural Molecule Activity
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