LINC02875 and APPL2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		LINC02875	APPL2
Description		long intergenic non-protein coding RNA 2875	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Image		No pdb structure
GO Annotations	Cellular Component		Ruffle Nucleus Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Vesicle Early Phagosome Ruffle Membrane Early Phagosome Membrane Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Bounding Membrane Of Organelle
	Molecular Function	Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process		Diet Induced Thermogenesis Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cold Acclimation Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Homeostatic Process Glucose Homeostasis Regulation Of Innate Immune Response Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of D-glucose Import Negative Regulation Of Neurogenesis Protein Homotetramerization Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS			Mosquito bite size ( 28199695)
Interacting Genes		7 interacting genes: APPL2 DAPK1 KDM1A PRMT6 SH2D2A SUV39H1 TRAF2	31 interacting genes: APPL1 ATF3 CNMD CRADD CRBN CRLF3 CRYAA DOK3 EPM2AIP1 HUNK KIFC3 KMT2C LDHAL6B LGALS9C LINC02875 LIX1 MLST8 MTA2 PINK1 POT1 PRR35 RAB22A RAB5A RAB5C RAI2 RBBP7 RBP7 RUVBL2 SUV39H2 TINF2 TSC1
Entrez ID		388407	55198
HPRD ID		14202	06945
Ensembl ID		ENSG00000187013	ENSG00000136044
Uniprot IDs			Q8NEU8
PDB IDs			4H8S 5C5B
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process DAPK1-calmodulin Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of Autophagic Cell Death Chromatin Binding TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Neural Precursor Cell Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Positive Regulation Of Cold-induced Thermogenesis Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Positive Regulation Of Macropinocytosis Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ENoSc Complex Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Early Phagosome Membrane Cold Acclimation Regulation Of NMDA Receptor Activity Cellular Response To Stress Regulation Of Protein Metabolic Process Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Regulation Of Multicellular Organismal Development Methyltransferase Activity RDNA Heterochromatin Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex MRF Binding Protein Demethylase Activity Regulation Of Cold-induced Thermogenesis Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Macropinosome Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process	Telomere Assembly Regulation Of Cellular Component Organization Response To Oxygen Levels Response To Decreased Oxygen Levels Plasma Membrane To Endosome Transport GDP Binding Early Phagosome NuRD Complex Chromosome, Telomeric Region Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Positive Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Nuclear Telomere Cap Complex Shelterin Complex Telomere Capping Protein Kinase B Binding TORC2 Signaling Protein Binding Regulation Of Vesicle Size Phagocytic Vesicle TOR Signaling Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cell Fate Specification Positive Regulation Of Cellular Component Organization Telomere Maintenance Protein Stabilization Ruffle Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Cellular Component Size Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Endomembrane System Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Memory T Cell Differentiation Protein Folding Chaperone Complex Epigenetic Programming Of Gene Expression Telomere Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Generation Of Precursor Metabolites And Energy Histone Methyltransferase Activity Positive Regulation Of Biosynthetic Process Response To Hypoxia Negative Regulation Of Macroautophagy
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