INSC and TTC23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		INSC	TTC23
Description		INSC spindle orientation adaptor protein	tetratricopeptide repeat domain 23
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex	Cilium Cell Projection
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization	Positive Regulation Of Smoothened Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 28869591 30598549) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)	Bell's palsy ( 33602968)
Interacting Genes		17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587	99 interacting genes: ABI1 ADCY4 AIRIM ALAS1 APP BANP BHLHE40 BLZF1 CBX8 CCDC102B CCDC24 CCNDBP1 CDK18 CDR2 CNTROB CREBZF CYSRT1 DISC1 EFCAB3 FAM161B FSD2 GOLGA2 GOLGA6L9 GPANK1 GPRASP2 GRIPAP1 HOOK2 HSF2BP HTT INSC KASH5 KDM1A KIAA1328 KLHL42 KRT15 KRT16 KRT27 KRT31 KRT34 KRT36 KRT40 KRTAP10-3 KRTAP10-8 LCN2 LDOC1 LZTS2 MAGED1 MBD3 MDFI MED12L MESD MID2 MKRN3 MTUS2 NOTO NUTM1 PICK1 PIH1D2 PLEKHG4 PNMA1 PNMA5 POLR2J3 POU6F2 PPP1R16A PRDM6 PRKAB2 PRPH PSORS1C2 RAD51D RBCK1 SPAG11B SPAG5 SPAG8 SPDEF SSX2IP TADA2A TEX13A TLE5 TRAF2 TRAPPC6A TRIB3 TRIM10 TRIM32 TRIM54 TRIM73 TRIP6 TSGA10IP UBXN11 USHBP1 XIAP XRN2 ZBED1 ZBTB16 ZBTB42 ZDHHC17 ZFHX3 ZFYVE26 ZIM2 ZRANB1
Entrez ID		387755	64927
HPRD ID		18803	07777
Ensembl ID		ENSG00000188487	ENSG00000103852
Uniprot IDs		Q1MX18	Q5W5X9
PDB IDs		3SF4
Enriched GO Terms of Interacting Partners?		Centrosome Localization Cell Cortex Establishment Of Centrosome Localization Organelle Localization Microtubule Cytoskeleton Organization Microtubule-based Process GDP-dissociation Inhibitor Activity Establishment Of Organelle Localization Cytoskeleton Organization GTPase Regulator Activity G-protein Alpha-subunit Binding Apical Junction Complex Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Brood Size Outer Acrosomal Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Spindle Localization Organelle Organization Spindle Localization Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Lateral Cell Cortex	Cytoskeleton Keratin Filament Identical Protein Binding Intermediate Filament Organization Protein Binding Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Asymmetric Cell Division Ubiquitin Protein Ligase Activity Positive Regulation Of Apoptotic Process Response To Herbicide Protein Serine/threonine Kinase Binding Transcription Coactivator Activity MRF Binding Positive Regulation Of Programmed Cell Death
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