INSC and GPSM2

Number of citations of the paper that reports this interaction (PubMedID 16458856)
0

Data Source:
HPRD (in vivo)

		INSC	GPSM2
Description		INSC spindle orientation adaptor protein	G protein signaling modulator 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex	Spindle Pole Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Nucleotide Binding G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding Protein Domain Specific Binding GTPase Regulator Activity Identical Protein Binding Dynein Complex Binding
	Biological Process	Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Response To Light Intensity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly
Pathways			G alpha (i) signalling events
Drugs
Diseases
GWAS		Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 28869591 30598549) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)	Fat distribution (HIV) ( 21897333)
Interacting Genes		17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587	17 interacting genes: AGR2 ARHGEF40 DLG4 FXR1 FXR2 GAS2L1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC LRRC8E NRIP1 NUMA1 WHRN
Entrez ID		387755	29899
HPRD ID		18803	06609
Ensembl ID		ENSG00000188487	ENSG00000121957
Uniprot IDs		Q1MX18	B4DIF1 P81274
PDB IDs		3SF4	3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2
Enriched GO Terms of Interacting Partners?		Centrosome Localization Cell Cortex Establishment Of Centrosome Localization Organelle Localization Microtubule Cytoskeleton Organization Microtubule-based Process GDP-dissociation Inhibitor Activity Establishment Of Organelle Localization Cytoskeleton Organization GTPase Regulator Activity G-protein Alpha-subunit Binding Apical Junction Complex Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Brood Size Outer Acrosomal Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Spindle Localization Organelle Organization Spindle Localization Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Lateral Cell Cortex	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Heterotrimeric G-protein Complex Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Adenylate Cyclase Regulator Activity Modulation Of Chemical Synaptic Transmission GTPase Activity Ciliary Basal Body Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Periphery GTP Binding Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Long-term Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Plasticity G Protein Activity G Protein-coupled Receptor Binding GDP Binding Positive Regulation Of Protein Localization To Cell Periphery Cell Division Regulation Of Biological Quality Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Translation Regulator Activity Regulation Of Cell Communication Regulation Of Signaling G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Protein Localization Cytoskeletal Anchor Activity Cytoplasm Microtubule Plus-end Dentate Gyrus Development Neuron Projection Negative Regulation Of Secretion By Cell Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Secretion P2Y1 Nucleotide Receptor Binding Negative Regulation Of Transport Cell Cortex Negative Regulation Of Insulin Secretion Positive Regulation Of Metabolic Process Regulation Of Mitotic Spindle Organization Midbody Positive Regulation Of Protein Localization Negative Regulation Of Peptide Secretion
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