INSC and PARD3B

Number of citations of the paper that reports this interaction (PubMedID 16458856)
0

Data Source:
HPRD (in vivo)

		INSC	PARD3B
Description		INSC spindle orientation adaptor protein	par-3 family cell polarity regulator beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex	Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Apical Junction Complex Anchoring Junction
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Protein Binding Phosphatidylinositol Binding
	Biological Process	Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization	Microtubule Cytoskeleton Organization Cell Adhesion Intracellular Protein Localization Establishment Of Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization
Pathways
Drugs
Diseases
GWAS		Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 28869591 30598549) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)	Adult body size ( 32376654) AIDS progression ( 21502085) Aluminium levels ( 26025379) Attention deficit hyperactivity disorder ( 30563984) Autism ( 22843504) Body mass index ( 28892062) Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132) General risk tolerance (MTAG) ( 30643258) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hip circumference adjusted for BMI ( 28552196) Hippocampal volume ( 25625606) Idiopathic dilated cardiomyopathy ( 29495422) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29617998 31959993 30054594 29785010) Knee osteoarthritis ( 18471798) Nicotine dependence symptom count ( 25555482) Post bronchodilator FEV1/FVC ratio ( 26634245) Triglyceride levels ( 32902719) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587	9 interacting genes: CASK GAA INSC MARK2 PARD6B RBM5 RPS6KA1 YWHAE YWHAG
Entrez ID		387755	117583
HPRD ID		18803	09795
Ensembl ID		ENSG00000188487	ENSG00000116117
Uniprot IDs		Q1MX18	Q8TEW8
PDB IDs		3SF4
Enriched GO Terms of Interacting Partners?		Centrosome Localization Cell Cortex Establishment Of Centrosome Localization Organelle Localization Microtubule Cytoskeleton Organization Microtubule-based Process GDP-dissociation Inhibitor Activity Establishment Of Organelle Localization Cytoskeleton Organization GTPase Regulator Activity G-protein Alpha-subunit Binding Apical Junction Complex Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Brood Size Outer Acrosomal Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Spindle Localization Organelle Organization Spindle Localization Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Lateral Cell Cortex	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Autolysosome Lumen Vacuolar Sequestering TORC1 Signaling Protein Domain Specific Binding Protein Sequestering Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Sucrose Metabolic Process Maltose Metabolic Process Negative Regulation Of TOR Signaling TOR Signaling Regulation Of Heart Rate By Hormone Focal Adhesion
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