INSC and TEKT3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		INSC	TEKT3
Description		INSC spindle orientation adaptor protein	tektin 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Protein-containing Complex Apical Cortex	Acrosomal Vesicle Acrosomal Membrane Outer Acrosomal Membrane Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Axonemal A Tubule Inner Sheath
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Protein Domain Specific Binding Protein-macromolecule Adaptor Activity	Protein Binding
	Biological Process	Nervous System Development Asymmetric Cell Division Regulation Of Asymmetric Cell Division Cell Differentiation Regulation Of Protein Stability Apical Protein Localization	Flagellated Sperm Motility Cilium Assembly Cilium Movement Involved In Cell Motility Regulation Of Brood Size
Pathways
Drugs
Diseases
GWAS		Expressive vocabulary in infants ( 25226531) Heel bone mineral density ( 28869591 30598549) Menarche (age at onset) ( 23667675) Obesity-related traits ( 23251661)	Preterm birth (maternal effect) ( 28877031) Resting heart rate ( 27798624)
Interacting Genes		17 interacting genes: CCDC187 GEM GPANK1 GPSM1 GPSM2 LHX3 LNX1 PARD3 PARD3B PRR35 RUSC1 SMARCD1 SORBS3 TEKT3 TTC23 USP54 ZNF587	33 interacting genes: AJUBA ARID5A ASPG ATN1 CALCOCO2 CNOT2 DDI1 GORASP2 HNRNPH1 IKZF3 INSC KRT34 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 LMO2 METTL27 OIP5 PLAGL2 PLEKHG4 RAMAC RFX6 SAXO5 SPAG8 TNS2 TRAF2 TRIB3 WWOX
Entrez ID		387755	64518
HPRD ID		18803	18173
Ensembl ID		ENSG00000188487	ENSG00000125409
Uniprot IDs		Q1MX18	Q9BXF9
PDB IDs		3SF4	7UNG
Enriched GO Terms of Interacting Partners?		Centrosome Localization Cell Cortex Establishment Of Centrosome Localization Organelle Localization Microtubule Cytoskeleton Organization Microtubule-based Process GDP-dissociation Inhibitor Activity Establishment Of Organelle Localization Cytoskeleton Organization GTPase Regulator Activity G-protein Alpha-subunit Binding Apical Junction Complex Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Brood Size Outer Acrosomal Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Of Spindle Localization Organelle Organization Spindle Localization Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Lateral Cell Cortex	Intermediate Filament
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