KRT5 and EVPL

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
HPRD (in vivo)

		KRT5	EVPL
Description		keratin 5	envoplakin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Structural Molecule Activity Cadherin Binding
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Regulation Of Antibacterial Peptide Production Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Deep white matter hyperintensities ( 32517579) Depressive symptom improvement ( 30468137) L-selectin levels ( 25576479) Metabolite levels ( 23823483) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		30 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PKP2 RNF26 TCHP UBE3A	14 interacting genes: CSTA DSP IVL KRT1 KRT10 KRT2 KRT5 LORICRIN PI3 PLEKHA5 PPL PSORS1C2 SPRR2A SPRR3
Entrez ID		3852	2125
HPRD ID		01010	03352
Ensembl ID		ENSG00000186081	ENSG00000167880
Uniprot IDs		P13647	B7ZLH8 K7EKI0 Q92817
PDB IDs		3TNU 6JFV	4QMD
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Cornified Envelope Peptide Cross-linking Keratinization Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Epidermal Cell Differentiation Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Epidermis Development Epithelial Cell Differentiation Keratin Filament Cytoskeleton Organization Protein Modification Process Structural Molecule Activity Wound Healing Supramolecular Fiber Organization Cytosol Extracellular Exosome Protein Heterotetramerization Tissue Development Protein Heterooligomerization Desmosome Positive Regulation Of Epidermis Development Response To Wounding Endopeptidase Inhibitor Activity Cytoplasm Protein Metabolic Process Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Polymerization Humoral Immune Response Antibacterial Humoral Response Regulation Of Epidermis Development Developmental Process Scaffold Protein Binding Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Copulation Organelle Organization Protein Tetramerization Peptidase Inhibitor Complex Peptidase Inhibitor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cellular Developmental Process Extracellular Space Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Keratinocyte Migration Cardiac Muscle Cell-cardiac Muscle Cell Adhesion
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