KRT5 and ALOX12B

Number of citations of the paper that reports this interaction (PMID 10727209)
7

Data Source:
HPRD (in vivo, two hybrid)

		KRT5	ALOX12B
Gene Name		keratin 5, type II	arachidonate 12-lipoxygenase, 12R type
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Linoleate 9S-lipoxygenase Activity
	Biological Process	Epidermis Development Hemidesmosome Assembly Cell Junction Assembly	Protein Lipidation Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonic Acid Metabolic Process Lipoxygenase Pathway Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		Cell junction organization Type I hemidesmosome assembly	Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 SUMO1 SUMO2 SUMO3 TCHP	2 interactors: KRT5 LMNA
Entrez ID		3852	242
HPRD ID		01010	04772
Ensembl ID		ENSG00000186081	ENSG00000179477
Uniprot IDs		P13647	O75342
PDB IDs		3TNU
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Skin Development Epidermis Development Establishment Of Skin Barrier Intermediate Filament Organization Regulation Of Water Loss Via Skin Protein Sumoylation Multicellular Organismal Water Homeostasis Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Intermediate Filament Bundle Assembly Cell Junction Assembly Water Homeostasis Bundle Of His Cell To Purkinje Myocyte Communication Anatomical Structure Development Cell-cell Junction Organization Positive Regulation Of Protein Catabolic Process Linoleic Acid Metabolic Process Desmosome Organization Hemidesmosome Assembly Lipoxygenase Pathway Developmental Process Positive Regulation Of Proteolysis Epithelium Development Long-chain Fatty Acid Biosynthetic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Action Potential Tissue Development Regulation Of Heart Rate By Cardiac Conduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Component Maintenance Positive Regulation Of Cellular Protein Catabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Single Organismal Cell-cell Adhesion Apoptotic Process Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Conduction Peptide Cross-linking Programmed Cell Death Cell-substrate Junction Assembly Cell Death Death	Sterol Regulatory Element Binding Protein Import Into Nucleus Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Cell Aging Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Hemidesmosome Assembly SREBP Signaling Pathway Response To Sterol Depletion Negative Regulation Of Release Of Cytochrome C From Mitochondria Ventricular Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Mitochondrion Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell-substrate Junction Assembly Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Tissue Development Nuclear Envelope Organization Cardiac Muscle Cell Development Execution Phase Of Apoptosis Endoplasmic Reticulum Unfolded Protein Response Regulation Of Mitochondrion Organization Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Cardiac Muscle Cell Differentiation Protein Import Into Nucleus Nucleus Organization Nuclear Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Cardiocyte Differentiation
Tagcloud ?		aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns
Tagcloud (Difference) ?		aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns
Tagcloud (Intersection) ?