KRT5 and ALOX12B

Number of citations of the paper that reports this interaction (PubMedID 10727209)
0

Data Source:
HPRD (in vivo, two hybrid)

		KRT5	ALOX12B
Description		keratin 5	arachidonate 12-lipoxygenase, 12R type
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Metal Ion Binding Arachidonate 8(R)-lipoxygenase Activity Dioxygenase Activity Arachidonate 12(R)-lipoxygenase Activity Linoleate 9S-lipoxygenase Activity
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Protein Lipidation Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonate Metabolic Process Lipoxygenase Pathway Lipid Oxidation Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Synthesis of 12-eicosatetraenoic acid derivatives
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease	Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		30 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PKP2 RNF26 TCHP UBE3A	2 interacting genes: KRT5 LMNA
Entrez ID		3852	242
HPRD ID		01010	04772
Ensembl ID		ENSG00000186081	ENSG00000179477
Uniprot IDs		P13647	O75342
PDB IDs		3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Structural Constituent Of Cytoskeleton Intermediate Filament Polymerization Intermediate Filament Intermediate Filament Polymerization Or Depolymerization DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Negative Regulation Of Mesenchymal Cell Proliferation Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Nuclear Lamina Protein Localization To Nuclear Envelope Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Localization Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Cell Migration Nuclear Migration Regulation Of Cell Motility Nucleus Localization Regulation Of Locomotion Regulation Of Mesenchymal Cell Proliferation Nuclear Lumen Negative Regulation Of Muscle Hypertrophy Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Release Of Cytochrome C From Mitochondria Cardiac Cell Development Structural Constituent Of Skin Epidermis Scaffold Protein Binding Keratinization Intermediate Filament Organization Striated Muscle Cell Development Protein-containing Complex Localization Regulation Of Cardiac Muscle Hypertrophy Cellular Senescence Protein Polymerization Chromosome Localization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Organization Muscle Cell Development Site Of Double-strand Break Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Telomere Maintenance Regulation Of Mitochondrion Organization
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