KRT5 and KRT25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT5	KRT25
Description		keratin 5	keratin 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis Scaffold Protein Binding	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity
	Biological Process	Epidermis Development Response To Mechanical Stimulus Regulation Of Cell Migration Keratinization Regulation Of Protein Localization Intermediate Filament Polymerization Intermediate Filament Organization	Morphogenesis Of An Epithelium Cytoskeleton Organization Epithelial Cell Differentiation Hair Follicle Morphogenesis Hair Cycle Intermediate Filament Organization
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Keratinization Formation of the cornified envelope
Drugs		Zinc Zinc acetate
Diseases		Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic Dowling-Degos disease
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Asthma ( 30929738 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		30 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT13 KRT14 KRT15 KRT18 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PKP2 RNF26 TCHP UBE3A	26 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT83 KRT85 KRT86 MORN4 PPL
Entrez ID		3852	147183
HPRD ID		01010	17242
Ensembl ID		ENSG00000186081	ENSG00000204897
Uniprot IDs		P13647	Q6ZPD6 Q7Z3Z0
PDB IDs		3TNU 6JFV
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Tissue Morphogenesis Epithelial Cell Differentiation Morphogenesis Of An Epithelium Cytoskeleton Organelle Organization Extracellular Exosome Cytosol Anatomical Structure Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Developmental Process Keratinization Cellular Developmental Process Cell Differentiation Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Desmosome Hair Cycle Peptide Cross-linking Arachidonate 12(S)-lipoxygenase Activity Wound Healing Anchoring Junction Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Hair Follicle Morphogenesis Adherens Junction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Establishment Of Skin Barrier Hepoxilin Biosynthetic Process Polymeric Cytoskeletal Fiber Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Skin Epidermis Development Intermediate Filament Bundle Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Lipoxygenase Pathway Negative Regulation Of Cyclin-dependent Protein Kinase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Regulation Of Ventricular Cardiac Muscle Cell Action Potential Keratinocyte Differentiation Desmosome Organization Scaffold Protein Binding	Keratinization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Extracellular Exosome Cytosol Cornified Envelope Epidermis Development Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Tissue Development Peptide Cross-linking Desmosome Intermediate Filament Polymerization Protein Binding Structural Molecule Activity Keratinocyte Activation Intermediate Filament Polymerization Or Depolymerization Negative Regulation Of Entry Of Bacterium Into Host Cell Response To Wounding
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