KRT5 and KRT18

Number of citations of the paper that reports this interaction (PMID 9786957)
23

Data Source:
HPRD (in vivo)

		KRT5	KRT18
Gene Name		keratin 5, type II	keratin 18, type I
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Vesicular Exosome	Nucleolus Cytoplasm Microtubule Organizing Center Intermediate Filament Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Structural Molecule Activity Protein Binding Poly(A) RNA Binding Scaffold Protein Binding
	Biological Process	Epidermis Development Hemidesmosome Assembly Cell Junction Assembly	Cell Cycle Anatomical Structure Morphogenesis Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process
Pathways		Cell junction organization Type I hemidesmosome assembly
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ALOX12 ALOX12B APC DSP DST EVPL KIFC3 KRT1 KRT14 KRT15 KRT18 KRT31 KRT38 KRT40 PKP2 SUMO1 SUMO2 SUMO3 TCHP	73 interactors: BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EGFR EP300 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 IKBKG KPNA2 KRT15 KRT5 KRT72 KRT8 LDOC1 MAPK14 NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE RAF1 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SUMO1 SVIL TCHP TNFRSF1B TRADD TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		3852	3875
HPRD ID		01010	01020
Ensembl ID		ENSG00000186081	ENSG00000111057
Uniprot IDs		P13647	P05783
PDB IDs		3TNU
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Skin Development Epidermis Development Establishment Of Skin Barrier Intermediate Filament Organization Regulation Of Water Loss Via Skin Protein Sumoylation Multicellular Organismal Water Homeostasis Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Intermediate Filament Bundle Assembly Cell Junction Assembly Water Homeostasis Bundle Of His Cell To Purkinje Myocyte Communication Anatomical Structure Development Cell-cell Junction Organization Positive Regulation Of Protein Catabolic Process Linoleic Acid Metabolic Process Desmosome Organization Hemidesmosome Assembly Lipoxygenase Pathway Developmental Process Positive Regulation Of Proteolysis Epithelium Development Long-chain Fatty Acid Biosynthetic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Action Potential Tissue Development Regulation Of Heart Rate By Cardiac Conduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Component Maintenance Positive Regulation Of Cellular Protein Catabolic Process Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Modification Single Organismal Cell-cell Adhesion Apoptotic Process Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Conduction Peptide Cross-linking Programmed Cell Death Cell-substrate Junction Assembly Cell Death Death	Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Regulation Of Apoptotic Process Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway ERBB Signaling Pathway Cellular Component Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Membrane Organization Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Organelle Organization Innate Immune Response Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transport Anatomical Structure Development Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Signaling Mitotic Cell Cycle Phase Transition Cellular Response To Fibroblast Growth Factor Stimulus Cell Cycle Phase Transition Enzyme Linked Receptor Protein Signaling Pathway Response To Fibroblast Growth Factor Developmental Process Defense Response Regulation Of Proteolysis Cellular Protein Localization Cellular Response To Stimulus
Tagcloud ?		aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		aldh1 ciliated columnar exposes foxj1 gynaecological hgsc hgscs krt7 layered lef1 mem membraneous nests outgrowths oviduct oviductal oviducts pax2 pseudostratified rcn1 scout scouts stathmin stins tubal walthard wcn wcns	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?