RBPMS and HEY2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		RBPMS	HEY2
Gene Name		RNA binding protein with multiple splicing	hes-related family bHLH transcription factor with YRPW motif 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Sin3 Complex Transcriptional Repressor Complex
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Binding Poly(A) Binding Poly(A) RNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Microsatellite Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Processing Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Anterior/posterior Axis Specification Positive Regulation Of Heart Rate Negative Regulation Of Transcription By Transcription Factor Localization Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Notch Signaling Involved In Heart Development Protein-DNA Complex Assembly Cochlea Development Vascular Smooth Muscle Cell Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Heart rate variability traits ( 22174390)
Protein-Protein Interactions		174 interactors: ADAM15 AES AMMECR1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0E2 ATXN1 BANP BBS2 BCL6B BHLHE40 BOLL C11orf87 C1orf111 C1orf94 C20orf195 C22orf39 C9orf24 CAMK2B CCER1 CCNG1 CCNK CDC23 CDC42EP1 CNNM3 CRBN CREB5 CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DMRT3 DOK3 DOK6 DPYSL4 DTX2 DVL2 EFEMP2 ENKD1 EWSR1 EYA2 FAM103A1 FAM124B FAM168A FASTK FBF1 FBXL18 FOXC2 FOXP3 FOXS1 FXR2 GCM2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 HEY2 HEYL HNRNPLL HOXA1 HOXA9 HOXB9 IGF2 ILF3 INCA1 INIP IP6K2 KCTD9 KIF1A KIR2DL4 KPNA2 KRAS KRTAP12-2 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP8-1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LMO4 LOC142937 LOC148413 LONRF1 LRRC41 LRRC75A-AS1 LZTS2 MAGED1 MCM5 MGAT5B MVP MYOZ2 NAB2 NAPRT NEDD9 NEU4 NR1D2 NYNRIN OTX1 PAPD4 PDLIM4 PER1 PGLS PHF1 PIH1D1 PIN1 PITX1 PLAC8 POGZ POM121 PRKAA1 PRKAA2 PRKAB2 PRR20A QKI R3HDM2 RABL6 RBFOX1 RBFOX2 RDH12 RHOBTB3 RHOXF2 RIPPLY1 ROR2 RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SH3RF2 SIRPB1 SMUG1 SNRPB SNRPC SPATA8 SPG7 STRBP TBX6 TEX37 TFG TIE1 TINAGL1 TMSB4X TOLLIP TOR1AIP2 TRIP13 TTLL10 TUSC2 VENTX VHL VHLL VPS37C WDR54 WDR90 WDYHV1 YPEL3 ZBTB32 ZC3H10 ZNF385C ZNF488 ZNF581	12 interactors: ARNT ATXN1 HAND1 HAND2 HDAC1 HES1 NCOR1 PLSCR1 RBPMS SIN3A SIRT1 TRAF1
Entrez ID		11030	23493
HPRD ID		11870	05243
Ensembl ID		ENSG00000157110	ENSG00000135547
Uniprot IDs		B4E3T4 D3DSV0 Q93062	Q5TF93 Q9UBP5
PDB IDs		1BNY
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Developmental Process Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Response To Stimulus Cellular Response To Stimulus Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Signaling Signal Transduction Cellular Metabolic Process Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Biosynthetic Process Regulation Of Circadian Rhythm Organ Development Insulin Receptor Signaling Pathway Cellular Process Response To Radiation	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Regulation Of Signaling Regulation Of DNA Binding Nucleobase-containing Compound Metabolic Process Regulation Of Transcription Regulatory Region DNA Binding Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Chromatin Silencing Negative Regulation Of Gene Expression Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Cardiac Right Ventricle Formation Negative Regulation Of DNA Binding In Utero Embryonic Development Histone Deacetylation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Protein Deacetylation Embryonic Heart Tube Morphogenesis Regulation Of Binding Negative Regulation Of Gene Expression, Epigenetic Circadian Regulation Of Gene Expression
Tagcloud ?			alterations anatomic astrocytoma astrocytomas biology braf grade hes1 hey1 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Difference) ?			alterations anatomic astrocytoma astrocytomas biology braf grade hes1 hey1 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable
Tagcloud (Intersection) ?