RBPMS and HEY2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		RBPMS	HEY2
Description		RNA binding protein, mRNA processing factor	hes related family bHLH transcription factor with YRPW motif 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	Nucleic Acid Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Molecular Adaptor Activity Pre-mRNA Intronic Binding MRNA CDS Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing Response To Oxidative Stress Positive Regulation Of DNA-templated Transcription SMAD Protein Signal Transduction Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Hypertrophy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Pattern Specification Process Heart Development Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation By RNA Polymerase II Labyrinthine Layer Blood Vessel Development Blood Vessel Endothelial Cell Differentiation Artery Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494 28017375) Mean corpuscular volume ( 29403010 32888494 28017375 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798) White blood cell count ( 32888494)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 35210625 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)
Interacting Genes		311 interacting genes: ABCF3 ACTMAP ADAM15 ALG13 AMMECR1 ANAPC11 ANKHD1 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 ATXN7L2 BAG4 BANP BBS2 BCAS2 BCL6B BHLHE40 BOLL C10orf55 C11orf87 C1orf94 C22orf39 CAMK2A CAMK2B CCDC120 CCER1 CCL14 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CEP55 CHCHD7 CIMIP1 CIMIP2B CLPP CNNM3 COL8A1 CPEB2 CPSF7 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DDX28 DMRT3 DMRTB1 DNTTIP2 DOK3 DOK6 DPYSL4 DTX2 DVL2 DYNC1I1 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EXOSC7 EYA2 FAM120A FAM124B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATA2 GATAD2B GCM2 GLIS2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 HCK HEY2 HEYL HIVEP1 HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KAT5 KCTD9 KIF1A KIR2DL4 KLHDC7B KPNA2 KRAS KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP26-1 KRTAP3-1 KRTAP8-1 LARP4B LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MAZ MBNL1 MBNL2 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MLLT10 MORN3 MRPL10 MRPL20-AS1 MRPL44 MSI2 MSX1 MVP MYH7B MYO1C MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NIP7 NKX2-5 NR1D2 NTAQ1 NXF1 NYNRIN OTX1 PATL1 PATZ1 PCBP2 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PITX2 PKP2 PLAC8 PLSCR4 POGZ POLDIP3 POLR3GL POM121 POU4F2 POU6F2 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRKRA PRPF6 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PRRC2B PSG11 PSMF1 PTBP3 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM22 RBM24 RBM42 RBM46 RBM7 RBPMS2 RDH12 RDX RHOBTB3 RHOXF2 RIPPLY1 RNF20 ROR2 RPP25 RPS27A RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SLAIN1 SLC25A48 SLIRP SMAD3 SMAP1 SMARCC2 SMUG1 SNHG29 SNRPB SNRPC SNRPG SNRPN SNW1 SPATA46 SPATA8 SPG7 SPMIP6 SPMIP9 STRBP TBX6 TCEA2 TCF7L2 TEKT5 TENT2 TFG TIE1 TINAGL1 TLE5 TMEM277P TMEM42 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSC1 TSG101 TSGA10IP TSPYL6 TTLL10 TUSC2 TXNL4A UBAP2 UNKL VENTX VEZF1 VGLL3 VHL VHLL VPS37C WBP4 WDR54 WDR90 YPEL3 YTHDF1 ZBTB32 ZC3H10 ZIC1 ZMAT5 ZNF34 ZNF385C ZNF488 ZNF581	27 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4
Entrez ID		11030	23493
HPRD ID		11870	05243
Ensembl ID		ENSG00000157110	ENSG00000135547
Uniprot IDs		B4E3T4 Q93062	Q5TF93 Q9UBP5
PDB IDs		5CYJ 5DET
Enriched GO Terms of Interacting Partners?		Nucleus Protein Binding RNA Binding Nucleic Acid Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Intermediate Filament MRNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression MRNA Binding Regulation Of Primary Metabolic Process RNA Processing Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Splicing Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Chromatin Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Metabolic Process Cytoplasmic Stress Granule RNA Splicing, Via Transesterification Reactions RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process	Intermediate Filament RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis HLH Domain Binding Cardiac Right Ventricle Formation Keratin Filament Chromatin Regulation Of Transcription By RNA Polymerase II Cytosol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Identical Protein Binding Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Heart Left/right Asymmetry Transcription Corepressor Binding Cardiac Ventricle Formation Negative Regulation Of Transcription By RNA Polymerase II Cartilage Morphogenesis E-box Binding Regulation Of Cardioblast Proliferation Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Artery Morphogenesis Cardiac Chamber Formation Protein Dimerization Activity Regulation Of Cellular Response To Growth Factor Stimulus DNA Binding Protein Deacetylation Protein Lysine Deacetylase Activity Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process
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