PLEKHM2 and SLC39A1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PLEKHM2	SLC39A1
Gene Name		pleckstrin homology domain containing, family M (with RUN domain) member 2	solute carrier family 39 (zinc transporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Kinesin Binding	Receptor Binding Zinc Ion Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity
	Biological Process	Golgi Organization	Cation Transport Transmembrane Transport Zinc Ion Transmembrane Transport
Pathways			Metal ion SLC transporters Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Zinc influx into cells by the SLC39 gene family Zinc transporters SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Lentiform nucleus volume ( 22903471)
Protein-Protein Interactions		2 interactors: KLC1 SLC39A1	8 interactors: CERS2 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2
Entrez ID		23207	27173
HPRD ID		11440	11984
Ensembl ID		ENSG00000116786	ENSG00000143570
Uniprot IDs		Q5VVD7 Q8IWE5	B4DDY7 Q9NY26
PDB IDs		3CXB 3HW2 3ZFW
Enriched GO Terms of Interacting Partners?		Stress Granule Disassembly Protein Localization To Synapse Zinc Ion Transmembrane Transport Zinc Ion Transport Organelle Disassembly Axon Cargo Transport	Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-13 Secretion Positive Regulation Of Interleukin-5 Secretion Synaptic Transmission Protein Heterooligomerization Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of T-helper 2 Cell Cytokine Production NADPH Oxidation Activation Of Phospholipase D Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Metal Ion Transport Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Cell-cell Signaling Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of T Cell Cytokine Production Cation Transmembrane Transport Positive Regulation Of T-helper 2 Cell Differentiation Glomerular Capillary Formation Learning Or Memory Regulation Of Interleukin-10 Secretion Cognition Positive Regulation Of Interleukin-4 Production Positive Regulation Of Insulin Receptor Signaling Pathway Angiogenesis Regulation Of T Cell Cytokine Production Cation Transport Regulation Of Interleukin-5 Production Glomerulus Morphogenesis Positive Regulation Of Type 2 Immune Response
Tagcloud ?		accounted attenuating effector enterica hydrolytic lysosomal lysosome lysosomes mannose mpr mprs noninfected pathogen potency rab9 replicates retrograde salmonella sequestration sifa skip subverted thereby trafficking translocated transported undergo vacuoles whose	aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic
Tagcloud (Difference) ?		accounted attenuating effector enterica hydrolytic lysosomal lysosome lysosomes mannose mpr mprs noninfected pathogen potency rab9 replicates retrograde salmonella sequestration sifa skip subverted thereby trafficking translocated transported undergo vacuoles whose	aco1 annotations atp7b caco conditioned dcytb duodenal enterocyte fech fth1 hemochromatosis heph hfe1 highlight invariant iron metabolism microarrays modulated nucleocytoplasmic ontological place regard slc11a2 slc11a3 taking tf transcriptomic xenobiotic
Tagcloud (Intersection) ?