PLEKHM2 and SLC39A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PLEKHM2	SLC39A1
Description		pleckstrin homology and RUN domain containing M2	solute carrier family 39 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Kinesin Binding	Signaling Receptor Binding Zinc Ion Transmembrane Transporter Activity Protein Binding Inorganic Cation Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity
	Biological Process	Golgi Organization Lysosome Localization Regulation Of Protein Localization Natural Killer Cell Mediated Cytotoxicity	In Utero Embryonic Development Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Metal Ion Transport Embryonic Cranial Skeleton Morphogenesis Transmembrane Transport Limb Development Zinc Ion Transmembrane Transport
Pathways			Zinc influx into cells by the SLC39 gene family
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 31015462)	Age at first birth ( 27798627) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Empathy quotient ( 29527006) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Lentiform nucleus volume ( 22903471) Raw vegetable consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		2 interacting genes: KLC1 SLC39A1	16 interacting genes: CERS2 COMT CXCL16 CXCL9 CYB561 HTR2C HTR4 KCNAB1 KCNAB2 NOTCH3 PLEKHM2 PRKCZ SHB SLC39A2 TRARG1 YIPF6
Entrez ID		23207	27173
HPRD ID		11440	11984
Ensembl ID		ENSG00000116786	ENSG00000143570
Uniprot IDs		Q8IWE5	A0A0A0MTL8 Q9NY26
PDB IDs		3CXB 3HW2 3ZFW 8JCA
Enriched GO Terms of Interacting Partners?		Stress Granule Disassembly Inorganic Cation Transmembrane Transporter Activity Embryonic Cranial Skeleton Morphogenesis Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Kinesin Complex Kinesin Binding Cytoskeletal Motor Activity Limb Development Organelle Disassembly Embryonic Skeletal System Morphogenesis	Membrane Serotonin Binding Serotonin Receptor Activity Serotonin Receptor Signaling Pathway Juxtaparanode Region Of Axon Alcohol Dehydrogenase (NADP+) Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Appetite Positive Regulation Of T-helper Cell Differentiation Behavioral Fear Response Behavioral Defense Response Plasma Membrane Norepinephrine Secretion Fear Response Catechol O-methyltransferase Activity Large Intestinal Transit Chemokine Activity Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Potassium Channel Regulator Activity Pinceau Fiber Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Regulation Of T-helper Cell Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Voltage-gated Potassium Channel Activity Positive Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Phosphate Starvation Cell-cell Signaling Cell Communication Response To Peptide Hormone Multicellular Organismal Response To Stress Signaling Digestive System Process Chemical Synaptic Transmission Ascorbate Homeostasis Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Transmembrane Transport Regulation Of Cell Differentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Activation
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