F11

Gene Name		coagulation factor XI
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Plasminogen Activation Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Coagulation Factor IX 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Response to statin therapy ( 20339536) Venous thromboembolism ( 21980494 23650146)
Protein-protein Interactions		7 interactors: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2
Entrez ID		2160
HPRD ID		07524
Ensembl ID		ENSG00000088926
Uniprot IDs		P03951
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Blood Coagulation, Intrinsic Pathway Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Cell Activation Negative Regulation Of Catalytic Activity Platelet Degranulation Response To Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Exocytosis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Inflammatory Response Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Tagcloud ?		adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning