F11 and SERPINA5

Number of citations of the paper that reports this interaction (PubMedID 2551064)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		F11	SERPINA5
Description		coagulation factor XI	serpin family A member 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Extracellular Matrix Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Serine-type Aminopeptidase Activity	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis Regulation Of Blood Coagulation Plasminogen Activation Positive Regulation Of Fibrinolysis	Lipid Transport Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Seminal Clot Liquefaction
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective F9 activation	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation
Drugs		Coagulation Factor IX (Recombinant) Human C1-esterase inhibitor 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonate (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinate (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidine 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidine N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidine Conestat alfa Thrombin Human thrombin Coagulation Factor IX Human Zinc chloride Zinc sulfate, unspecified form	Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases		Factor XI deficiency; Plasma thromboplastin antecedent deficiency; Rosenthal syndrome
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Cardiac troponin-I levels ( 31014085) Factor XI ( 28053049) L-arginine levels ( 27656708) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)	Blood protein levels ( 30072576) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010)
Interacting Genes		7 interacting genes: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2	22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD
Entrez ID		2160	5104
HPRD ID		07524	03503
Ensembl ID		ENSG00000088926	ENSG00000188488
Uniprot IDs		D6RB32 P03951	B4DDH1 P05154
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4CR5 4CR9 4CRA 4CRB 4CRC 4CRD 4CRE 4CRF 4CRG 4D76 4D7F 4D7G 4NA7 4NA8 4TY6 4TY7 4WXI 4X6M 4X6N 4X6O 4X6P 4Y8X 4Y8Y 4Y8Z 5E2O 5E2P 5EOD 5EOK 5EXL 5EXM 5EXN 5I25 5Q0D 5Q0E 5Q0F 5Q0G 5Q0H 5QCK 5QCL 5QCM 5QCN 5QQO 5QQP 5QTT 5QTV 5QTW 5QTY 5TKS 5TKT 5TKU 5WB6 6AOD 6C0S 6HHC 6I58 6R8X 6TS4 6TS5 6TS6 6TS7 6TWB 6USY 6VLU 6VLV 6W50 7CJ1 7MBO 7QOT 7V0Z 7V10 7V11 7V12 7V13 7V14 7V15 7V16 7V17 7V18 8BO3 8BO4 8BO5 8BO6 8BO7	1LQ8 2HI9 2OL2 3DY0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Fibrinolysis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Regulation Of Wound Healing Extracellular Matrix Regulation Of Response To Wounding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Extracellular Space Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Blood Microparticle Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Heparin Binding Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Extracellular Region Positive Regulation Of Coagulation Regulation Of Collagen Biosynthetic Process Acute-phase Response Regulation Of Collagen Metabolic Process Regulation Of Platelet Activation Positive Regulation Of Wound Healing Platelet Activation External Side Of Plasma Membrane Acute Inflammatory Response Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Proteolysis Signaling Receptor Binding Endopeptidase Activity	Zymogen Activation Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Blood Coagulation Hemostasis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Hemostasis Serine-type Peptidase Activity Serine-type Endopeptidase Activity Fibrinolysis Protein Processing Regulation Of Wound Healing Proteolysis Regulation Of Response To Wounding Regulation Of Body Fluid Levels Regulation Of Fibrinolysis Protein Maturation Peptidase Activity Extracellular Space Protein Metabolic Process Regulation Of Biological Quality Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Region Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process Protein Activation Cascade Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Hydrolase Activity External Side Of Plasma Membrane Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Protein Maturation Positive Regulation Of Wound Healing Blood Coagulation, Common Pathway Platelet Activation Platelet Alpha Granule Negative Regulation Of Protein Maturation Positive Regulation Of Vasoconstriction Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Secretory Granule Positive Regulation Of Fibrinolysis Regulation Of Protein Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?