F11 and SERPINF2

Number of citations of the paper that reports this interaction (PMID 8703832)
1

Data Source:
HPRD (in vivo)

		F11	SERPINF2
Gene Name		coagulation factor XI	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Plasminogen Activation Positive Regulation Of Fibrinolysis	Regulation Of Blood Vessel Size By Renin-angiotensin Platelet Degranulation Acute-phase Response Blood Coagulation Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Platelet Activation Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs		Coagulation Factor IX 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE	Ocriplasmin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Response to statin therapy ( 20339536) Venous thromboembolism ( 21980494 23650146)	Calcium levels ( 20705733) Serum albumin level ( 23022100)
Protein-Protein Interactions		7 interactors: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2	17 interactors: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2
Entrez ID		2160	5345
HPRD ID		07524	02029
Ensembl ID		ENSG00000088926	ENSG00000167711
Uniprot IDs		P03951	P08697
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Blood Coagulation, Intrinsic Pathway Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Cell Activation Negative Regulation Of Catalytic Activity Platelet Degranulation Response To Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Exocytosis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Inflammatory Response Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway	Extracellular Matrix Disassembly Proteolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Wound Healing Negative Regulation Of Wound Healing Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Response To Wounding Blood Coagulation Hemostasis Protein Metabolic Process Regulation Of Blood Coagulation Regulation Of Wound Healing Regulation Of Body Fluid Levels Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Stress Vesicle-mediated Transport Regulation Of Fibrinolysis Mitochondrial Calcium Ion Homeostasis Cobalamin Metabolic Process Exocytosis Killing Of Cells Of Other Organism Defense Response To Fungus Fibrinolysis Protein Activation Cascade Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell-substrate Adhesion Response To Fungus Secretion By Cell Immune System Process Peptide Cross-linking Protein Processing Tissue Regeneration Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Blood Coagulation, Common Pathway Blood Coagulation, Common Pathway Regulation Of Cell Adhesion Secretion Collagen Catabolic Process Cellular Calcium Ion Homeostasis Cell Activation Calcium Ion Homeostasis Cellular Homeostasis Positive Regulation Of Signal Transduction Collagen Metabolic Process
Tagcloud ?		adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning
Tagcloud (Difference) ?		adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning
Tagcloud (Intersection) ?