F11 and GP1BA

Number of citations of the paper that reports this interaction (PubMedID 11696542)
0

Data Source:
HPRD (in vitro)

		F11	GP1BA
Description		coagulation factor XI	glycoprotein Ib platelet subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Serine-type Aminopeptidase Activity	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Proteolysis Blood Coagulation Hemostasis Regulation Of Blood Coagulation Plasminogen Activation Positive Regulation Of Fibrinolysis	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway
Pathways		Intrinsic Pathway of Fibrin Clot Formation Defective F9 activation	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Coagulation Factor IX (Recombinant) Human C1-esterase inhibitor 3-Hydroxypropyl 3-[(7-carbamimidoyl-1-naphthyl)carbamoyl]benzenesulfonate (1R)-2-[(Diaminomethylene)amino]-1-{4-[(4R)-4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl]phenyl}ethyl nicotinate (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenethyl)guanidine 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(Hydroxymethyl)-1,3,2-dioxaborolan-2-YL)phenyl)guanidine N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(hydroxymethyl)-1,3,2-dioxaborolan-2-yl)benzyl)guanidine Conestat alfa Thrombin Human thrombin Coagulation Factor IX Human Zinc chloride Zinc sulfate, unspecified form	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		Factor XI deficiency; Plasma thromboplastin antecedent deficiency; Rosenthal syndrome	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Cardiac troponin-I levels ( 31014085) Factor XI ( 28053049) L-arginine levels ( 27656708) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Thrombosis ( 26908601) Venous thromboembolism ( 21980494 23650146 25772935 28373160 31420334 31676865)	Blood protein levels ( 30072576) Keratoconus ( 33649486) Mean platelet volume ( 27863252 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		2160	2811
HPRD ID		07524	01976
Ensembl ID		ENSG00000088926	ENSG00000185245
Uniprot IDs		D6RB32 P03951	L7UYB8 P07359
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS 4CR5 4CR9 4CRA 4CRB 4CRC 4CRD 4CRE 4CRF 4CRG 4D76 4D7F 4D7G 4NA7 4NA8 4TY6 4TY7 4WXI 4X6M 4X6N 4X6O 4X6P 4Y8X 4Y8Y 4Y8Z 5E2O 5E2P 5EOD 5EOK 5EXL 5EXM 5EXN 5I25 5Q0D 5Q0E 5Q0F 5Q0G 5Q0H 5QCK 5QCL 5QCM 5QCN 5QQO 5QQP 5QTT 5QTV 5QTW 5QTY 5TKS 5TKT 5TKU 5WB6 6AOD 6C0S 6HHC 6I58 6R8X 6TS4 6TS5 6TS6 6TS7 6TWB 6USY 6VLU 6VLV 6W50 7CJ1 7MBO 7QOT 7V0Z 7V10 7V11 7V12 7V13 7V14 7V15 7V16 7V17 7V18 8BO3 8BO4 8BO5 8BO6 8BO7	1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Body Fluid Levels Fibrinolysis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Regulation Of Wound Healing Extracellular Matrix Regulation Of Response To Wounding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Extracellular Space Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Fibrinolysis Blood Microparticle Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Heparin Binding Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Multicellular Organismal Process Extracellular Region Positive Regulation Of Coagulation Regulation Of Collagen Biosynthetic Process Acute-phase Response Regulation Of Collagen Metabolic Process Regulation Of Platelet Activation Positive Regulation Of Wound Healing Platelet Activation External Side Of Plasma Membrane Acute Inflammatory Response Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Proteolysis Signaling Receptor Binding Endopeptidase Activity	Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?