F11 and GP1BA

Number of citations of the paper that reports this interaction (PMID 11696542)
4

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		F11	GP1BA
Gene Name		coagulation factor XI	glycoprotein Ib (platelet), alpha polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Serine-type Aminopeptidase Activity	Protein Binding Thrombin Receptor Activity
	Biological Process	Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Plasminogen Activation Positive Regulation Of Fibrinolysis	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Platelet Activation Regulation Of Blood Coagulation Fibrinolysis Thrombin Receptor Signaling Pathway
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Coagulation Factor IX 3-HYDROXYPROPYL 3-[({7-[AMINO(IMINO)METHYL]-1-NAPHTHYL}AMINO)CARBONYL]BENZENESULFONATE (1R)-2-{[AMINO(IMINO)METHYL]AMINO}-1-{4-[(4R)-4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL]PHENYL}ETHYL NICOTINATE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENETHYL)GUANIDINE 6-CARBAMIMIDOYL-4-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-NAPHTHALENE-2-CARBOXYLIC ACID METHYL ESTER (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)PHENYL)GUANIDINE N-(7-CARBAMIMIDOYL-NAPHTHALEN-1-YL)-3-HYDROXY-2-METHYL-BENZAMIDE 4-METHYL-PENTANOIC ACID {1-[4-GUANIDINO-1-(THIAZOLE-2-CARBONYL)-BUTYLCARBAMOYL]-2-METHYL-PROPYL}-AMIDE (R)-1-(4-(4-(HYDROXYMETHYL)-1,3,2-DIOXABOROLAN-2-YL)BENZYL)GUANIDINE	Alpha-D-Mannose
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Response to statin therapy ( 20339536) Venous thromboembolism ( 21980494 23650146)	Platelet counts ( 22139419 20139978)
Protein-Protein Interactions		7 interactors: F2 GP1BA HGF KNG1 SERPINA5 SERPINF2 TFPI2	16 interactors: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP SELP TPST1 VWF YWHAZ
Entrez ID		2160	2811
HPRD ID		07524	01976
Ensembl ID		ENSG00000088926	ENSG00000185245
Uniprot IDs		P03951	E7ES66
PDB IDs		1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8 3SOR 3SOS
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Platelet Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Blood Coagulation, Intrinsic Pathway Regulation Of Blood Coagulation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Cell Activation Negative Regulation Of Catalytic Activity Platelet Degranulation Response To Stress Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Metabolic Process Positive Regulation Of Blood Coagulation Regulation Of Collagen Metabolic Process Acute-phase Response Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Exocytosis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Catalytic Activity Inflammatory Response Regulation Of Blood Vessel Size Regulation Of Tube Size Acute Inflammatory Response Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway	Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Platelet Activation Protein Activation Cascade Regulation Of Blood Coagulation Cell Activation Response To Stress Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Inflammatory Response Regulation Of Fibrinolysis Platelet Degranulation Defense Response Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Response To Stimulus Exocytosis Positive Regulation Of Fibrinolysis Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Secretion By Cell MRNA Transcription From RNA Polymerase II Promoter MRNA Transcription Secretion Negative Regulation Of Platelet Activation Cell Adhesion Regulation Of Ion Homeostasis Cellular Extravasation Fibrinolysis Cytosolic Calcium Ion Homeostasis Leukocyte Migration Positive Regulation Of Intracellular Transport Protein Processing Cellular Localization Negative Regulation Of Determination Of Dorsal Identity Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Acute Inflammatory Response Positive Regulation Of Transport Establishment Of Localization In Cell Threonylcarbamoyladenosine Biosynthetic Process
Tagcloud ?		adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning	acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2
Tagcloud (Difference) ?		adopts antiparallel buried cavity cdr1 cdr3 centre complexed crystallographic distorting fab hairpin hydroxyl hypervariable inh intermolecular loops ordered p42 p45 peptide polar protease proteolysis proteolytic protruding refined sheet spanning	acantholysis anxa8l1 atp2c1 blistering c5a cd1b cd32 cd88 cdh8 cdh9 chrm3 chrnd chrne col21a1 cyb5b desmoglein dra dsc1 dsc3 justifies mucocutaneous multiplexed ndufs1 pdha1 pemphigus pkp3 pmp22 slc36a4 sod2
Tagcloud (Intersection) ?