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KLRC2 and HLA-E
Number of citations of the paper that reports this interaction (PMID
9486650
)
214
Data Source:
HPRD
(in vivo)
KLRC2
HLA-E
Gene Name
killer cell lectin-like receptor subfamily C, member 2
major histocompatibility complex, class I, E
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Golgi Membrane
Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
MHC Class I Protein Complex Binding
Carbohydrate Binding
Protein Antigen Binding
Receptor Binding
Beta-2-microglobulin Binding
MHC Class I Protein Binding
Peptide Antigen Binding
Biological Process
Natural Killer Cell Mediated Immunity
Cellular Defense Response
Signal Transduction
Innate Immune Response
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Regulation Of Natural Killer Cell Mediated Immunity
Positive Regulation Of Natural Killer Cell Mediated Immunity
Cytokine-mediated Signaling Pathway
Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Pathways
DAP12 signaling
DAP12 interactions
Innate Immune System
DAP12 interactions
Interferon Signaling
Cytokine Signaling in Immune system
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Interferon gamma signaling
DAP12 signaling
Endosomal/Vacuolar pathway
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Antigen processing-Cross presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
ER-Phagosome pathway
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
3 interactors:
FBP1
HLA-E
KLRD1
7 interactors:
B2M
CALR
CD8A
KLRC1
KLRC2
KLRD1
PPP1R16A
Entrez ID
3822
3133
HPRD ID
04202
00877
Ensembl ID
ENSG00000205809
ENSG00000204592
Uniprot IDs
P26717
A8K8M6
O19682
P13747
Q6DU44
PDB IDs
2L35
1KPR
1KTL
1MHE
2ESV
3AM8
3BZE
3BZF
3CDG
3CII
Enriched GO Terms of Interacting Partners
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Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib
Cellular Response To Magnesium Ion
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Glycolytic Process
Antigen Processing And Presentation Of Endogenous Antigen
Fructose Metabolic Process
Response To Magnesium Ion
Positive Regulation Of Natural Killer Cell Mediated Immunity
Fructose 6-phosphate Metabolic Process
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Natural Killer Cell Mediated Immunity
Natural Killer Cell Mediated Immunity
Regulation Of Glycolytic Process
Innate Immune Response
Regulation Of Immune Response
Negative Regulation Of Innate Immune Response
Regulation Of Gluconeogenesis
Gluconeogenesis
Cellular Response To Drug
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Small GTPase Mediated Signal Transduction
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Hexose Biosynthetic Process
Immune Response
Protein Homotetramerization
Regulation Of Immune System Process
Defense Response
Regulation Of Generation Of Precursor Metabolites And Energy
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Protein Tetramerization
Positive Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cell Killing
Regulation Of Glucose Metabolic Process
Regulation Of Leukocyte Mediated Cytotoxicity
Type I Interferon Signaling Pathway
Cellular Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Response To Type I Interferon
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Metal Ion
Negative Regulation Of Immune Response
Cellular Response To Inorganic Substance
Glucose Metabolic Process
Cellular Response To Interferon-gamma
Positive Regulation Of Adaptive Immune Response
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Regulation Of Immune System Process
Natural Killer Cell Mediated Immunity
Regulation Of Immune Response
Leukocyte Mediated Immunity
Antigen Processing And Presentation
Immune System Process
Immune Response
Signal Transduction
Defense Response
Signaling
Cell Communication
Peptide Antigen Assembly With MHC Class I Protein Complex
Cytotoxic T Cell Differentiation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Response To Stress
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Cellular Response To Stimulus
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
T Cell Differentiation
Innate Immune Response
Sequestering Of Calcium Ion
Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent
Antigen Processing And Presentation Of Peptide Antigen
Lymphocyte Differentiation
Positive Regulation Of Dendritic Cell Chemotaxis
Response To Stimulus
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Glucocorticoid Receptor Signaling Pathway
Leukocyte Aggregation
Protein Folding
Sequestering Of Metal Ion
Leukocyte Cell-cell Adhesion
Protein Maturation By Protein Folding
Response To Metal Ion
Homotypic Cell-cell Adhesion
Leukocyte Differentiation
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Cellular Response To Lithium Ion
Protein Refolding
Metal Ion Homeostasis
Response To Inorganic Substance
Leukocyte Activation
Regulation Of Defense Response To Virus By Virus
Cortical Actin Cytoskeleton Organization
Response To Drug
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Calcium-mediated Signaling
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