KLRC2 and KLRD1

Number of citations of the paper that reports this interaction (PMID 10320637)
1

Data Source:
HPRD (in vivo)

		KLRC2	KLRD1
Gene Name		killer cell lectin-like receptor subfamily C, member 2	killer cell lectin-like receptor subfamily D, member 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding
	Biological Process	Natural Killer Cell Mediated Immunity Cellular Defense Response Signal Transduction Innate Immune Response	Natural Killer Cell Mediated Immunity Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response
Pathways		DAP12 signaling DAP12 interactions Innate Immune System	DAP12 signaling DAP12 interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: FBP1 HLA-E KLRD1	6 interactors: HLA-B HLA-E HLA-G KLRC1 KLRC2 KLRC3
Entrez ID		3822	3824
HPRD ID		04202	04204
Ensembl ID		ENSG00000205809	ENSG00000134539
Uniprot IDs		P26717	F6WZH4 Q13241 Q53ZY6
PDB IDs		2L35	1B6E 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Cellular Response To Magnesium Ion Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Glycolytic Process Antigen Processing And Presentation Of Endogenous Antigen Fructose Metabolic Process Response To Magnesium Ion Positive Regulation Of Natural Killer Cell Mediated Immunity Fructose 6-phosphate Metabolic Process Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Glycolytic Process Innate Immune Response Regulation Of Immune Response Negative Regulation Of Innate Immune Response Regulation Of Gluconeogenesis Gluconeogenesis Cellular Response To Drug Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Hexose Biosynthetic Process Immune Response Protein Homotetramerization Regulation Of Immune System Process Defense Response Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Protein Tetramerization Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Glucose Metabolic Process Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Negative Regulation Of Immune Response Cellular Response To Inorganic Substance Glucose Metabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity Cellular Defense Response Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Cell Differentiation Positive Regulation Of Adaptive Immune Response Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Defense Response Response To Interferon-gamma Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Regulation Of Immune Response Antigen Processing And Presentation Negative Regulation Of Innate Immune Response Negative Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Immune Response Regulation Of Interleukin-12 Production Regulation Of Immune System Process Signal Transduction Signaling Cell Communication Cellular Response To Cytokine Stimulus Positive Regulation Of Immune Response Response To Stress Negative Regulation Of Immune Response Response To Cytokine Cellular Response To Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune System Process Positive Regulation Of Immune System Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive Regulation Of Regulatory T Cell Differentiation
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