KLRC2 and FBP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		KLRC2	FBP1
Gene Name		killer cell lectin-like receptor subfamily C, member 2	fructose-1,6-bisphosphatase 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding Protein Antigen Binding	Protein Binding AMP Binding Fructose 1,6-bisphosphate 1-phosphatase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding
	Biological Process	Natural Killer Cell Mediated Immunity Cellular Defense Response Signal Transduction Innate Immune Response	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Pathogenesis Dephosphorylation Negative Regulation Of Cell Growth Cellular Response To Drug Small Molecule Metabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Protein Homotetramerization Cellular Response To Magnesium Ion
Pathways		DAP12 signaling DAP12 interactions Innate Immune System	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: FBP1 HLA-E KLRD1	20 interactors: ACTN1 ASCC2 ASL ATP5J2 BCL2L1 BIN1 CSNK1E DYNC1I1 FBP2 FXR2 HDAC6 HSPA8 KLRC2 LNX1 PARK2 PCNXL4 POT1 PTK2 RNF183 TERF1
Entrez ID		3822	2203
HPRD ID		04202	01973
Ensembl ID		ENSG00000205809	ENSG00000165140
Uniprot IDs		P26717	P09467 Q2TU34
PDB IDs		2L35	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1
Enriched GO Terms of Interacting Partners?		Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Cellular Response To Magnesium Ion Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Glycolytic Process Antigen Processing And Presentation Of Endogenous Antigen Fructose Metabolic Process Response To Magnesium Ion Positive Regulation Of Natural Killer Cell Mediated Immunity Fructose 6-phosphate Metabolic Process Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Immunity Regulation Of Glycolytic Process Innate Immune Response Regulation Of Immune Response Negative Regulation Of Innate Immune Response Regulation Of Gluconeogenesis Gluconeogenesis Cellular Response To Drug Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Hexose Biosynthetic Process Immune Response Protein Homotetramerization Regulation Of Immune System Process Defense Response Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Protein Tetramerization Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Glucose Metabolic Process Regulation Of Leukocyte Mediated Cytotoxicity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Interferon-gamma-mediated Signaling Pathway Cellular Response To Metal Ion Negative Regulation Of Immune Response Cellular Response To Inorganic Substance Glucose Metabolic Process Cellular Response To Interferon-gamma Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I	Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Aggresome Assembly Positive Regulation Of Oxidative Stress-induced Cell Death Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Anoikis Regulation Of Telomerase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Death Regulation Of Anoikis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Telomere Maintenance Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Fibril Organization Apoptotic Process In Bone Marrow Positive Regulation Of Mitochondrial Fusion Positive Regulation Of DNA Strand Elongation Hsp90 Deacetylation Positive Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?			abundantly albeit antagonizes bccip fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored stably suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Difference) ?			abundantly albeit antagonizes bccip fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored stably suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Intersection) ?