KIF2A and KLC2

Number of citations of the paper that reports this interaction (PubMedID 17332754)
32

Data Source:
HPRD (in vivo)

		KIF2A	KLC2
Description		kinesin family member 2A	kinesin light chain 2
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Nucleolus Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Membrane Nuclear Body Ciliary Basal Body Mitotic Spindle Centriolar Subdistal Appendage	Nucleoplasm Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Cytosol Cytoskeleton Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity	Protein Binding Kinesin Binding Cadherin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Microtubule Cytoskeleton Organization Microtubule-based Movement Microtubule Depolymerization Mitotic Spindle Organization Nervous System Development Cell Differentiation Regulation Of Cell Migration Cell Division Mitotic Spindle Assembly	Microtubule-based Movement Lysosome Localization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)	Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: CASK CEBPA CLSTN1 DYNLT1 FAM13C FXR2 H3-4 KLC1 KLC2 LARP1B LMO2 LMO3 MRPL53 SUMO2	17 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 LRRK2 MAPK8IP3 PIK3R3 PRC1 RUSC2 S100A8 TRIB1 YWHAG YWHAQ YWHAZ
Entrez ID		3796	64837
HPRD ID		03996	13917
Ensembl ID		ENSG00000068796	ENSG00000174996
Uniprot IDs		A0A6Q8PFA6 B0AZS5 O00139	Q9H0B6
PDB IDs		2GRY 6BBN	3CEQ 3EDT
Enriched GO Terms of Interacting Partners?		Kinesin Binding	Kinesin Binding Cytosol Microtubule Binding Growth Cone Transmembrane Transporter Binding Cytoskeletal Motor Activity Cellular Response To Manganese Ion Microtubule-based Movement RAGE Receptor Binding Response To Manganese Ion Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Microtubule-based Process Response To Catecholamine Intracellular Signaling Cassette Regulation Of Synapse Organization Intracellular Signal Transduction Regulation Of Synapse Maturation Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Regulation Of Immune System Process Positive Regulation Of Inflammatory Response Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Transport Along Microtubule Amylin Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Differentiation Positive Regulation Of Toll Signaling Pathway Regulation Of Apoptotic Process Regulation Of CAMP/PKA Signal Transduction Regulation Of Programmed Cell Death Cytoplasm Regulation Of MAPK Cascade Microtubule Vesicle Spindle Pole Kinesin Complex Spindle Microtubule S100A8 Complex Cellular Response To Starvation Regulation Of Protein Stability Protein Sequestering Activity X11-like Protein Binding Signaling Receptor Complex Adaptor Activity Cellular Response To Curcumin Caveola Neck
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