KCNA5 and SUMO3

Number of citations of the paper that reports this interaction (PMID 17261810)
32

Data Source:
BioGRID (enzymatic study)

		KCNA5	SUMO3
Gene Name		potassium channel, voltage gated shaker related subfamily A, member 5	small ubiquitin-like modifier 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Intercalated Disc Z Disc Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding	Protein Binding SUMO Transferase Activity
	Biological Process	Response To Hypoxia Potassium Ion Transport Synaptic Transmission Regulation Of Vasoconstriction Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Transport Regulation Of Insulin Secretion Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Potassium Channels Voltage gated Potassium channels	SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ACTN2 DLG1 DLG4 ERBB2IP KCNA2 PTPRE SNTA1 SRC SUMO3 TNK2	53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM
Entrez ID		3741	6612
HPRD ID		08888	03754
Ensembl ID		ENSG00000130037	ENSG00000184900
Uniprot IDs		P22460	B4DUW4 P55854
PDB IDs			1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Endocytosis Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Synaptic Transmission Cell-cell Junction Organization Muscle Contraction Actin Filament-based Process Regulation Of Sodium Ion Transmembrane Transport Peptidyl-tyrosine Autophosphorylation Muscle System Process Movement Of Cell Or Subcellular Component Receptor Clustering Nucleotide Phosphorylation Signaling Regulation Of Potassium Ion Transport Regulation Of Insulin Receptor Signaling Pathway Cell Communication Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell-cell Signaling Regulation Of Vesicle-mediated Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Axon Guidance Regulation Of Cellular Response To Insulin Stimulus Cellular Component Assembly Protein Complex Assembly Action Potential Regulation Of Cellular Localization Adherens Junction Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Activation Cytoskeleton Organization Optic Nerve Structural Organization Basal Protein Localization Cellular Response To Progesterone Stimulus Cell Projection Organization Cell Adhesion Regulation Of Cellular Process Regulation Of Receptor Activity	Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?		advance channel doi es ewing gated hypoxic kv kv1 nb onc online overexpress pcg polycomb potassium prerequisite publication reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Difference) ?		advance channel doi es ewing gated hypoxic kv kv1 nb onc online overexpress pcg polycomb potassium prerequisite publication reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage	aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation
Tagcloud (Intersection) ?