KCNA5 and TNK2

Number of citations of the paper that reports this interaction (PubMedID 14506255)
0

Data Source:
BioGRID (pull down, enzymatic study)

		KCNA5	TNK2
Description		potassium voltage-gated channel subfamily A member 5	tyrosine kinase non receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Cell Surface Intercalated Disc Membrane Z Disc Monoatomic Ion Channel Complex Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Grb2-EGFR Complex Cytoophidium
	Molecular Function	Signaling Receptor Binding Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Bundle Of His Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Repolarization Scaffold Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	Action Potential Response To Hypoxia Monoatomic Ion Transport Potassium Ion Transport Notch Signaling Pathway Response To Mechanical Stimulus Regulation Of Vasoconstriction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Response To Hydrogen Peroxide Regulation Of Insulin Secretion Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Transmembrane Transport Response To Hyperoxia Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Membrane Repolarization During Bundle Of His Cell Action Potential Membrane Repolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation	Endocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Voltage gated Potassium channels Phase 3 - rapid repolarisation	Signaling by LTK
Drugs		Enflurane Promethazine Miconazole Vernakalant Dalfampridine Isavuconazole	ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases		Atrial fibrillation
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Longevity ( 30294719)	Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		11 interacting genes: ACTN2 DLG1 DLG4 ERBIN KCNA2 PTPRE SNTA1 SRC TMEM107 TNK2 UBE2I	52 interacting genes: AKT1 AQP1 AR ARSL ATP5F1A BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R1 PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 UBC VTI1B WAS WWOX WWP2 YES1
Entrez ID		3741	10188
HPRD ID		08888	06104
Ensembl ID		ENSG00000130037	ENSG00000061938
Uniprot IDs		P22460	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 A0A5F9ZHP4 A0A5F9ZI29 B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM 7KP6 8FE9 8FZ3 8HMT 8Q5P 8THA
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Cell Junction Anchoring Junction Neuromuscular Junction Glutamatergic Synapse Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Transport Juxtaparanode Region Of Axon Postsynaptic Density Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Angiotensin-activated Signaling Pathway Cell Adhesion Focal Adhesion Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Potassium Ion Transport Cellular Component Assembly Plasma Membrane Protein Localization To Postsynaptic Membrane Adherens Junction Protein Localization To Postsynapse Regulation Of Heart Contraction Regulation Of Sodium Ion Transmembrane Transport Cell-substrate Junction Assembly Regulation Of Vesicle-mediated Transport Cell-substrate Junction Organization Regulation Of System Process Regulation Of Biological Quality Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Localization To Cell Periphery Receptor Localization To Synapse Regulation Of Cell Morphogenesis Receptor Clustering Regulation Of Blood Circulation Cell Junction Assembly Regulation Of Monoatomic Cation Transmembrane Transport Actin Filament Uncapping Protein Localization To Synapse P2Y1 Nucleotide Receptor Binding SUMO Conjugating Enzyme Activity Regulation Of Monoatomic Ion Transmembrane Transport Perinuclear Region Of Cytoplasm Epidermal Growth Factor Receptor Signaling Pathway Synaptic Membrane Regulation Of Multicellular Organismal Process Cytoskeletal Protein Binding Protein Localization To Membrane	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell-cell Junction Ephrin Receptor Binding Signal Transduction Cell Migration Cell Motility Regulation Of Cell Projection Organization Intracellular Signal Transduction Regulation Of Signal Transduction Leukocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization T Cell Costimulation Actin Filament Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Cell Activation Regulation Of Apoptotic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Lymphocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Actin Filament Organization Positive Regulation Of Locomotion Regulation Of Protein Localization To Plasma Membrane Plasma Membrane Protein Autophosphorylation Cell Differentiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Biological Quality Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Locomotion
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