KCNA5 and TNK2

Number of citations of the paper that reports this interaction (PMID 14506255)
19

Data Source:
BioGRID (pull down, enzymatic study)

		KCNA5	TNK2
Gene Name		potassium channel, voltage gated shaker related subfamily A, member 5	tyrosine kinase, non-receptor, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Intercalated Disc Z Disc Potassium Channel Complex Membrane Raft Intracellular Canaliculus Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endosome Plasma Membrane Coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Axon Dendrite Growth Cone Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Grb2-EGFR Complex
	Molecular Function	Receptor Binding Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Alpha-actinin Binding Voltage-gated Potassium Channel Activity Involved In Atrial Cardiac Muscle Cell Action Potential Repolarization Scaffold Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Metal Ion Binding WW Domain Binding Hormone Receptor Binding
	Biological Process	Response To Hypoxia Potassium Ion Transport Synaptic Transmission Regulation Of Vasoconstriction Regulation Of Membrane Potential Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Transport Regulation Of Insulin Secretion Protein Homooligomerization Negative Regulation Of Cytosolic Calcium Ion Concentration Potassium Ion Homeostasis Membrane Hyperpolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Myoblast Proliferation	Endocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Small GTPase Mediated Signal Transduction Phosphorylation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-mediated Endocytosis
Pathways		Potassium Channels Voltage gated Potassium channels
Drugs			Adenosine triphosphate Debromohymenialdisine
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ACTN2 DLG1 DLG4 ERBB2IP KCNA2 PTPRE SNTA1 SRC SUMO3 TNK2	41 interactors: AQP1 AR ARSE BAG3 CDC42 CLTC CSPG4 CTTN EGFR FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NL NPHP1 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SIAH1 SMURF1 SNX9 SRC SRSF5 VTI1B WAS WWOX WWP2 YES1
Entrez ID		3741	10188
HPRD ID		08888	06104
Ensembl ID		ENSG00000130037	ENSG00000061938
Uniprot IDs		P22460	B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Endocytosis Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Synaptic Transmission Cell-cell Junction Organization Muscle Contraction Actin Filament-based Process Regulation Of Sodium Ion Transmembrane Transport Peptidyl-tyrosine Autophosphorylation Muscle System Process Movement Of Cell Or Subcellular Component Receptor Clustering Nucleotide Phosphorylation Signaling Regulation Of Potassium Ion Transport Regulation Of Insulin Receptor Signaling Pathway Cell Communication Regulation Of Sodium Ion Transport Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cell-cell Signaling Regulation Of Vesicle-mediated Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Axon Guidance Regulation Of Cellular Response To Insulin Stimulus Cellular Component Assembly Protein Complex Assembly Action Potential Regulation Of Cellular Localization Adherens Junction Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Activation Cytoskeleton Organization Optic Nerve Structural Organization Basal Protein Localization Cellular Response To Progesterone Stimulus Cell Projection Organization Cell Adhesion Regulation Of Cellular Process Regulation Of Receptor Activity	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Phagocytosis Endocytosis Fc Receptor Signaling Pathway Signaling Positive Regulation Of Signal Transduction Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Developmental Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Neuron Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Apoptotic Process Anatomical Structure Development Neuron Projection Development Locomotion Immune Response-regulating Signaling Pathway Cell Migration Regulation Of Cell Death Leukocyte Migration Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Neuron Differentiation T Cell Costimulation Cell Projection Organization Neurogenesis Axon Guidance Nervous System Development Vesicle-mediated Transport Positive Regulation Of Protein Complex Assembly Regulation Of Intracellular Signal Transduction Movement Of Cell Or Subcellular Component System Development Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Generation Of Neurons Neuron Projection Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Multicellular Organismal Development Positive Regulation Of Immune Response Negative Regulation Of Signal Transduction
Tagcloud ?		advance channel doi es ewing gated hypoxic kv kv1 nb onc online overexpress pcg polycomb potassium prerequisite publication reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage	ack1 acquire addiction cdc42 demethylase deprivation deregulated doi explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies onc publication reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Difference) ?		advance channel es ewing gated hypoxic kv kv1 nb online overexpress pcg polycomb potassium prerequisite reasoned relapse remission repression repressive resist restore sensitizes survive tumorigenicity voltage	ack1 acquire addiction cdc42 demethylase deprivation deregulated explosion facets fuel functionality genotoxic hoxa1 insults jhdm2a kdm3a modifies reality rtk rtks shuttles soon transduce uncovered unfold wherein
Tagcloud (Intersection) ?		doi onc publication